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TRPM7 Is Involved in Volume Regulation in Salivary Glands
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, J. M. | - |
dc.contributor.author | Choi, S. | - |
dc.contributor.author | Park, K. | - |
dc.creator | 박경표 | - |
dc.date.accessioned | 2019-04-24T08:31:02Z | - |
dc.date.available | 2020-04-05T08:31:02Z | - |
dc.date.created | 2018-08-30 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.citation | Journal of Dental Research, Vol.96 No.9, pp.1044-1050 | - |
dc.identifier.issn | 0022-0345 | - |
dc.identifier.uri | https://hdl.handle.net/10371/147978 | - |
dc.description.abstract | Under hypotonic conditions, the regulatory volume decrease (RVD) is essential to maintain physiological homeostasis and functions in diverse biological systems. Intracellular Ca2+ has been reported as an important mediator of this response, but the underlying Ca2+ mechanism responsible for RVD is still controversial. Here we investigate the role of Ca2+ in the RVD response using live-cell imaging, microspectrofluorimetry, and a patch-clamp technique. A typical RVD was observed in submandibular gland acinar cells after swelling in a hypotonic solution, whereas intracellular Ca2+ chelation completely inhibited the RVD response. The incidence and magnitude of the Ca2+ transient were proportional to the degree of hypotonicity of the extracellular medium, and there was a close relationship between intracellular Ca2+ concentration and the volumetric changes of the cells. Notably, this response was mediated by Ca2+-induced Ca2+ release, which is triggered by Ca2+ influx via stretch-activated TRPM7 channels. Furthermore, we detected the generation of Cl- currents in the swelling acinar cells upon hypotonic stress, and the current profile matched that of the Ca2+-activated Cl- currents. A specific inhibitor of Cl- currents also inhibited the RVD response. In conclusion, an intracellular Ca2+ increase in response to osmotically induced cell swelling plays a critical role in RVD in salivary gland acinar cells. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | SAGE Publications | - |
dc.title | TRPM7 Is Involved in Volume Regulation in Salivary Glands | - |
dc.type | Article | - |
dc.identifier.doi | 10.1177/0022034517708766 | - |
dc.citation.journaltitle | Journal of Dental Research | - |
dc.identifier.wosid | 000406054800011 | - |
dc.identifier.scopusid | 2-s2.0-85025664695 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201719757 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A001677 | - |
dc.description.srnd | CITE_RATE:5.38 | - |
dc.description.srnd | DEPT_NM:치의과학과 | - |
dc.description.srnd | EMAIL:kppark@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.citation.endpage | 1050 | - |
dc.citation.number | 9 | - |
dc.citation.startpage | 1044 | - |
dc.citation.volume | 96 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, K. | - |
dc.identifier.srnd | T201719757 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PAROTID ACINAR-CELLS | - |
dc.subject.keywordPlus | CORNEAL EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | ACTIVATED CA2+ ENTRY | - |
dc.subject.keywordPlus | CHLORIDE CHANNELS | - |
dc.subject.keywordPlus | INTRACELLULAR CALCIUM | - |
dc.subject.keywordPlus | LACRIMAL GLAND | - |
dc.subject.keywordPlus | DECREASE RVD | - |
dc.subject.keywordPlus | LINE SMG-C6 | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | cell biology | - |
dc.subject.keywordAuthor | cell signaling | - |
dc.subject.keywordAuthor | mechanotransduction | - |
dc.subject.keywordAuthor | molecular biology | - |
dc.subject.keywordAuthor | physiology | - |
dc.subject.keywordAuthor | signal transduction | - |
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