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Showing results 1 to 8 of 8

Issue Date	Title / Author(s) / Citation	File	Altmetrics
2018-03	Comprehensive PBPK model of rifampicin for quantitative prediction of complex drug-drug interactions: CYP3A/2C9 induction and OATP inhibition effects Asaumi, Ryuta; Toshimoto, Kota; Tobe, Yoshifusa; Hashizume, Kenta; Ken-ichi Nunoya; Imawaka, Haruo; Lee, Woo In; Sugiyama, Yuichi CPT: Pharmacometrics and Systems Pharmacology, Vol.7 No.3, pp.186-196	DOI
2018-05	Physiologically based pharmacokinetic modeling of bosentan identifies the saturable hepatic uptake as a major contributor to its nonlinear pharmacokinetics Sato, Masanobu; Toshimoto, Kota; Tomaru, Atsuko; Yoshikado, Takashi; Tanaka, Yuta; Hisaka, Akihiro; Lee, Wooin; Sugiyama, Yuichi Drug Metabolism and Disposition, Vol.46 No.5, pp.740-748	DOI
2018-07	Application of PBPK modeling and virtual clinical study approaches to predict the outcomes of CYP2D6 genotype-guided dosing of tamoxifen Nakamura, Toshimichi; Toshimoto, Kota; Lee, Wooin; Imamura, Chiyo K.; Tanigawara, Yusuke; Sugiyama, Yuichi CPT: Pharmacometrics and Systems Pharmacology, Vol.7 No.7, pp.474-482	DOI
2019-06	Physiologically-Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter-Mediated Interactions Between Metformin and Cimetidine Nishiyama, Kotaro; Toshimoto, Kota; Lee, Wooin; Ishiguro, Naoki; Bister, Bojan; Sugiyama, Yuichi CPT: Pharmacometrics and Systems Pharmacology, Vol.8 No.6, pp.396-406	DOI
2021-01	A Simple Decision Tree Suited for Identification of Early Oral Drug Candidates With Likely Pharmacokinetic Nonlinearity by Intestinal CYP3A Saturation Tomaru, Atsuko; Toshimoto, Kota; Lee, Wooin; Ishigame, Keiko; Sugiyama, Yuichi Journal of Pharmaceutical Sciences, Vol.110 No.1, pp.510-516	DOI
2021-01	Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes Yoshikado, Takashi; Lee, Wooin; Toshimoto, Kota; Morita, Kiyoe; Kiriake, Aya; Chu, Xiaoyan; Lee, Nora; Kimoto, Emi; Varma, Manthena V. S.; Kikuchi, Ryota; Scialis, Renato J.; Shen, Hong; Ishiguro, Naoki; Lotz, Ralf; Li, Albert P.; Maeda, Kazuya; Kusuhara, Hiroyuki; Sugiyama, Yuichi Journal of Pharmaceutical Sciences, Vol.110 No.1, pp.376-387	DOI
2021-01	Improved Prediction of the Drug-Drug Interactions of Pemafibrate Caused by Cyclosporine A and Rifampicin via PBPK Modeling: Consideration of the Albumin-Mediated Hepatic Uptake of Pemafibrate and Inhibition Constants With Preincubation Against OATP1B Park, Ji Eun; Shitara, Yoshihisa; Lee, Wooin; Morita, Shigemichi; Sahi, Jasminder; Toshimoto, Kota; Sugiyama, Yuichi Journal of Pharmaceutical Sciences, Vol.110 No.1, pp.517-528	DOI
2021-04	Revisiting Nonlinear Bosentan Pharmacokinetics by Physiologically Based Pharmacokinetic Modeling: Target Binding, Albeit Not a Major Contributor to Nonlinearity, Can Offer Prediction of Target Occupancy Koyama, Satoshi; Toshimoto, Kota; Lee, Wooin; Aoki, Yasunori; Sugiyama, Yuichi Drug Metabolism and Disposition, Vol.49 No.4, pp.298-304	DOI

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