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Direct (CN)-C-11-labeling of unprotected peptides via palladium mediated sequential cross-coupling reactions

DC Field Value Language
dc.contributor.authorZhao, Wenjun-
dc.contributor.authorLee, Hong Geun-
dc.contributor.authorBuchwald, Stephen L.-
dc.contributor.authorHooker, Jacob M.-
dc.creator이홍근-
dc.date.accessioned2019-04-24T08:31:09Z-
dc.date.available2020-04-05T08:31:09Z-
dc.date.created2018-12-10-
dc.date.created2018-12-10-
dc.date.issued2017-05-
dc.identifier.citationJournal of the American Chemical Society, Vol.139 No.21, pp.7152-7155-
dc.identifier.issn0002-7863-
dc.identifier.urihttps://hdl.handle.net/10371/148005-
dc.description.abstractA practical procedure for (CN)-C-11-labeling of unprotected peptides has been developed. The method was shown to be highly chemoselective for cysteine over other potentially nucleophilic residues, and the radiolabeled products were synthesized and purified in less than 15 min. Appropriate for biomedical applications, the method could be used on an extremely small scale (20 nmol) with a high radiochemical yield. The success of the protocol stems from the use of a Pd-reagent based on a dihaloarene, which enables direct nucleophile-nucleophile coupling of the peptide and [C-11]cyanide by temporal separation of nucleophile addition.-
dc.language영어-
dc.language.isoenen
dc.publisherAmerican Chemical Society-
dc.titleDirect (CN)-C-11-labeling of unprotected peptides via palladium mediated sequential cross-coupling reactions-
dc.typeArticle-
dc.identifier.doi10.1021/jacs.7b02761-
dc.citation.journaltitleJournal of the American Chemical Society-
dc.identifier.wosid000402691800006-
dc.identifier.scopusid2-s2.0-85019983347-
dc.description.srndOAIID:RECH_ACHV_DSTSH_NO:T201720243-
dc.description.srndRECH_ACHV_FG:RR00200001-
dc.description.srndADJUST_YN:-
dc.description.srndEMP_ID:A080564-
dc.description.srndCITE_RATE:14.357-
dc.description.srndFILENAME:1. jacs.7b02761.pdf-
dc.description.srndDEPT_NM:화학부-
dc.description.srndEMAIL:hgleee@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndFILEURL:https://srnd.snu.ac.kr/eXrepEIR/fws/file/c921a502-d7cb-44bd-a29b-4fed08a8ee78/link-
dc.citation.endpage7155-
dc.citation.number21-
dc.citation.startpage7152-
dc.citation.volume139-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorLee, Hong Geun-
dc.identifier.srndT201720243-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusPOSITRON-EMISSION-TOMOGRAPHY-
dc.subject.keywordPlusRADIOLABELED PEPTIDES-
dc.subject.keywordPlusPET-
dc.subject.keywordPlusCOMPLEXES-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusC-11-
dc.subject.keywordPlusRADIOPHARMACEUTICALS-
dc.subject.keywordPlusRADIOMETALS-
dc.subject.keywordPlusPROTEINS-
dc.subject.keywordPlusTHERAPY-
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