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Virtually instantaneous, room-temperature [11C]-cyanation using biaryl phosphine Pd(0) complexes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hong Geun | - |
dc.contributor.author | Milner, Phillip J. | - |
dc.contributor.author | Placzek, MichaelS. | - |
dc.contributor.author | Buchwald, Stephen L. | - |
dc.contributor.author | Hooker, Jacob M. | - |
dc.creator | 이홍근 | - |
dc.date.accessioned | 2019-04-24T08:31:19Z | - |
dc.date.available | 2020-04-05T08:31:19Z | - |
dc.date.created | 2018-11-07 | - |
dc.date.created | 2018-11-07 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.citation | Journal of the American Chemical Society, Vol.137 No.2, pp.648-651 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | https://hdl.handle.net/10371/148015 | - |
dc.description.abstract | A new radiosynthetic protocol for the preparation of [C-11]aryl nitriles has been developed. This process is based on the direct reaction of in situ prepared L Pd(Ar)X complexes (L = biaryl phosphine) with [C-11]HCN. The strategy is operationally simple, exhibits a remarkably wide substrate scope with short reaction times, and demonstrates superior reactivity compared to previously reported systems. With this procedure, a variety of [C-11]nitrile-containing pharmaceuticals were prepared with high radiochemical efficiency. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | American Chemical Society | - |
dc.title | Virtually instantaneous, room-temperature [11C]-cyanation using biaryl phosphine Pd(0) complexes | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/ja5121155 | - |
dc.citation.journaltitle | Journal of the American Chemical Society | - |
dc.identifier.wosid | 000348483400025 | - |
dc.identifier.scopusid | 2-s2.0-84921501454 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201720258 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A080564 | - |
dc.description.srnd | CITE_RATE:13.038 | - |
dc.description.srnd | FILENAME:6. ja512115s.pdf | - |
dc.description.srnd | DEPT_NM:화학부 | - |
dc.description.srnd | EMAIL:hgleee@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | FILEURL:https://srnd.snu.ac.kr/eXrepEIR/fws/file/41934f39-aadb-4f3a-be95-3258f1c2dc6b/link | - |
dc.citation.endpage | 651 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 648 | - |
dc.citation.volume | 137 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Hong Geun | - |
dc.identifier.srnd | T201720258 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PALLADIUM-CATALYZED CYANATION | - |
dc.subject.keywordPlus | RECEPTOR ANTAGONIST | - |
dc.subject.keywordPlus | C-11 | - |
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