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PTP1B inhibitors from the seeds of Iris sanguinea and their insulin mimetic activities via AMPK and ACC phosphorylation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Jun Li | - |
dc.contributor.author | Ha, Thi Kim Quy | - |
dc.contributor.author | Lee, Ba Wool | - |
dc.contributor.author | Kim, Jinwoong | - |
dc.contributor.author | Oh, Won Keun | - |
dc.creator | 오원근 | - |
dc.date.accessioned | 2019-04-24T08:35:22Z | - |
dc.date.available | 2020-04-05T08:35:22Z | - |
dc.date.created | 2018-02-06 | - |
dc.date.issued | 2017-11 | - |
dc.identifier.citation | Bioorganic and Medicinal Chemistry Letters, Vol.27 No.22, pp.5076-5081 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://hdl.handle.net/10371/148288 | - |
dc.description.abstract | To find PTP1B inhibitors from natural products, two new compounds (1 and 2), along with nine known compounds (3–11), were isolated from a methanol-soluble extract of Iris sanguinea seeds. The structures of compounds 1 and 2 were determined based on extensive spectroscopic data analysis including UV, IR, NMR, and MS. The IC50 value of compound 5 on protein tyrosine phosphatase 1B (PTP1B) inhibitory activity is 7.30 ± 0.88 µM with a little activity compared to the IC50 values of the tested positive compound. Compound 5 significantly enhanced glucose uptake and activation of pACC, pAMPK and partially Erk1/2 signaling. These results suggest that compound 5 from Iris sanguinea seeds are utilized as both PTP1B inhibitors and regulators of glucose uptake. These beneficial effects could be applied to treat metabolic diseases such as diabetes and obesity. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | Pergamon Press Ltd. | - |
dc.title | PTP1B inhibitors from the seeds of Iris sanguinea and their insulin mimetic activities via AMPK and ACC phosphorylation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bmcl.2017.09.031 | - |
dc.citation.journaltitle | Bioorganic and Medicinal Chemistry Letters | - |
dc.identifier.wosid | 000414000000027 | - |
dc.identifier.scopusid | 2-s2.0-85029759757 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201723906 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A079209 | - |
dc.description.srnd | CITE_RATE:2.442 | - |
dc.description.srnd | DEPT_NM:약학과 | - |
dc.description.srnd | EMAIL:wkoh1@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.citation.endpage | 5081 | - |
dc.citation.number | 22 | - |
dc.citation.startpage | 5076 | - |
dc.citation.volume | 27 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Jinwoong | - |
dc.contributor.affiliatedAuthor | Oh, Won Keun | - |
dc.identifier.srnd | T201723906 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PROTEIN-TYROSINE PHOSPHATASES | - |
dc.subject.keywordPlus | TRITERPENOIDS | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | SESQUITERPENES | - |
dc.subject.keywordPlus | DEFICIENCY | - |
dc.subject.keywordPlus | DISCOVERY | - |
dc.subject.keywordPlus | FLOWERS | - |
dc.subject.keywordPlus | LEAVES | - |
dc.subject.keywordAuthor | Iris sanguinea | - |
dc.subject.keywordAuthor | Triterpene | - |
dc.subject.keywordAuthor | PTP1B | - |
dc.subject.keywordAuthor | AMPK | - |
dc.subject.keywordAuthor | Glucose uptake | - |
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