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Functional restoration of replicative senescent mesenchymal stem cells by the brown alga Undaria pinnatifida
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Sin-Gu | - |
dc.contributor.author | Oh, Youn Seo | - |
dc.contributor.author | Joe, I-Seul | - |
dc.contributor.author | Jeong, So Young | - |
dc.contributor.author | Cho, Hyo Moon | - |
dc.contributor.author | Lee, Jun Sik | - |
dc.contributor.author | Oh, Won Keun | - |
dc.contributor.author | Cho, Tae Oh | - |
dc.contributor.author | Cho, Goang-Won | - |
dc.creator | 오원근 | - |
dc.date.accessioned | 2019-04-24T08:35:25Z | - |
dc.date.available | 2020-04-05T08:35:25Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2017-02 | - |
dc.identifier.citation | Animal Cells and Systems, Vol.21 No.2, pp.108-114 | - |
dc.identifier.issn | 1976-8354 | - |
dc.identifier.uri | https://hdl.handle.net/10371/148296 | - |
dc.description.abstract | The brown alga Undaria pinnatifida, which is called Mi-Yoek in Korea, has been traditionally consumed as a health food in East Asian countries. Recent studies have reported that U. pinnatifida has beneficial effects on arteriosclerosis, inflammation, fat metabolism, and tumors. In this study, we examined the anti-senescence effects of ethanol extracts of U. pinnatifida (UPEx) in human bone marrow mesenchymal stem cells (hBM-MSCs). UP-Ex protected hBM-MSCs against oxidative injury, as determined by MTT assays. This effect was confirmed by immunoblot analysis of the oxidation-sensitive protein p53 and the apoptotic protein cleaved caspase-3. Excessive intracellular reactive oxygen species (ROS) accumulation induced by oxidative stress was moderated in UP-Ex-treated hBM-MSCs (UP-Ex-MSCs). Similarly, expression of the ROS-scavenging enzymes superoxide dismutase 1 (SOD1), SOD2, and catalase was recovered in UPEx-MSCs. Excessive ROS induced by long-term cell expansion (passage 17) was significantly decreased along with restoration of the senescence proteins p53, p21, and p16 in UP-Ex-MSCs. UP-Ex treatment also improved the ability of these replicative, senescent hBM-MSCs (passage 17) to differentiate into osteocytes or adipocytes, suggesting that UP-Ex ameliorates the functional decline of senescent stem cells and may provide better therapeutic efficacy in stem cell therapy. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | 한국통합생물학회 | - |
dc.title | Functional restoration of replicative senescent mesenchymal stem cells by the brown alga Undaria pinnatifida | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/19768354.2017.1292951 | - |
dc.citation.journaltitle | Animal Cells and Systems | - |
dc.identifier.wosid | 000399657000005 | - |
dc.identifier.scopusid | 2-s2.0-85014458589 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201723973 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A079209 | - |
dc.description.srnd | CITE_RATE:.544 | - |
dc.description.srnd | DEPT_NM:약학과 | - |
dc.description.srnd | EMAIL:wkoh1@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.citation.endpage | 114 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 108 | - |
dc.citation.volume | 21 | - |
dc.identifier.kciid | ART002217828 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Oh, Won Keun | - |
dc.identifier.srnd | T201723973 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | FUCOIDAN | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | ACCUMULATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | DECREASE | - |
dc.subject.keywordPlus | SEAWEED | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | Undaria pinnatifida | - |
dc.subject.keywordAuthor | replicative senescence | - |
dc.subject.keywordAuthor | long-term expansion | - |
dc.subject.keywordAuthor | anti-oxidation | - |
dc.subject.keywordAuthor | mesenchymal stromal cells | - |
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