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Quantitative single-photon emission computed tomography/computed tomography for glomerular filtration rate measurement
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Yeon-koo | - |
dc.contributor.author | Park, Sohyun | - |
dc.contributor.author | Suh, Min Seok | - |
dc.contributor.author | Byun, Seok-Soo | - |
dc.contributor.author | Chae, Dong-Wan | - |
dc.contributor.author | Lee, Won Woo | - |
dc.creator | 이원우 | - |
dc.date.accessioned | 2019-04-24T23:01:00Z | - |
dc.date.available | 2020-04-05T23:01:00Z | - |
dc.date.created | 2018-07-17 | - |
dc.date.created | 2018-07-17 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.citation | Nuclear Medicine and Molecular Imaging, Vol.51 No.4, pp.338-346 | - |
dc.identifier.issn | 1869-3474 | - |
dc.identifier.uri | https://hdl.handle.net/10371/148617 | - |
dc.description.abstract | Purpose We propose a quantitative Tc-99m diethylenetriaminepentaacetic acid (DTPA) single-photon emission computed tomography/computed tomography (SPECT/CT) for glomerular filtration rate (GFR) measurement. Methods Quantitative SPECT/CT data obtained at 2-3 min post-Tc-99m DTPA injection (370 MBq) were used to determine % injected doses (%IDs) for individual kidneys. The reproducibility of %ID measurement was tested and compared with planar scintigraphy. Cr-51 ethylenediaminetetraacetic acid (EDTA) GFR was used as reference standard. Nine young volunteers, representing normal GFR, and ten older volunteers, reflecting impaired GFR, were enrolled. The established GFR equation derived from these volunteers was applied to 19 renal tumor patients post-partial nephrectomy. Results At 2-3 min, %ID was most reproducible with the highest intraclass correlation (ICC) (0.9379) and lowest % coefficient of variation (CV) (6.5259%), which were more reliable than the ICC (0.9368) and %CV (6.7689%) of planar scintigraphy. Cr-51 EDTA GFR (93.16 +/- 24.81 ml/min) correlated significantly with %ID (7.66 +/- 2.15%, r = 0.7906, p = 0.0001), yielding an equation: Cr-51 EDTA GFR (ml/min) = (%ID x 9.1462) + 23.0653. This equation revealed significant decreases in total and nephrectomized kidney GFR (p = 0.0012 and p < 0.0001, respectively) from preoperative to 3-month postoperative measurements. Conclusions Quantitative Tc-99m DTPA SPECT/CT produces reliable and clinically applicable %ID estimates that translate to the GFR of individual kidneys. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | 대한핵의학회 | - |
dc.title | Quantitative single-photon emission computed tomography/computed tomography for glomerular filtration rate measurement | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s13139-017-0491-8 | - |
dc.citation.journaltitle | Nuclear Medicine and Molecular Imaging | - |
dc.identifier.scopusid | 2-s2.0-85037661716 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201719351 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A079779 | - |
dc.description.srnd | CITE_RATE:0 | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | EMAIL:wwlee@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.citation.endpage | 346 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 338 | - |
dc.citation.volume | 51 | - |
dc.identifier.kciid | ART002291958 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Byun, Seok-Soo | - |
dc.contributor.affiliatedAuthor | Chae, Dong-Wan | - |
dc.contributor.affiliatedAuthor | Lee, Won Woo | - |
dc.identifier.srnd | T201719351 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CHRONIC KIDNEY-DISEASE | - |
dc.subject.keywordPlus | PARTIAL NEPHRECTOMY | - |
dc.subject.keywordPlus | RENAL-DISEASE | - |
dc.subject.keywordPlus | WARM ISCHEMIA | - |
dc.subject.keywordPlus | TC-99M DTPA | - |
dc.subject.keywordPlus | FORMULAS | - |
dc.subject.keywordPlus | EQUATION | - |
dc.subject.keywordPlus | SPECT/CT | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | INULIN | - |
dc.subject.keywordAuthor | Computed tomography | - |
dc.subject.keywordAuthor | Cr-51 EDTA | - |
dc.subject.keywordAuthor | Glomerular filtration rate | - |
dc.subject.keywordAuthor | Single-photon emission computed tomography | - |
dc.subject.keywordAuthor | Tc-99m DTPA | - |
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