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Marine Toxin Okadaic Acid Affects the Immune Function of Bay Scallop (Argopecten irradians)

Cited 13 time in Web of Science Cited 17 time in Scopus
Authors
박세창
Issue Date
2016-09
Publisher
MDPI AG
Citation
MOLECULES Vol.21 No.9, pp. 1-MAX
Keywords
Marine Toxin Okadaic Acid Affects the Immune Function of Bay Scallop (Argopecten irradians)자연과학
Abstract
Okadaic acid (OA) is produced by dinoflagellates during harmful algal blooms and is a diarrhetic shellfish poisoning toxin. This toxin is particularly problematic for bivalves that are cultured for human consumption. This study aimed to reveal the effects of exposure to OA on the immune responses of bay scallop, Argopecten irradians. Various immunological parameters were assessed (total hemocyte counts (THC), reactive oxygen species (ROS), malondialdehyde (MDA), glutathione (GSH), lactate dehydrogenase (LDH), and nitric oxide (NO) in the hemolymph of scallops at 3, 6, 12, 24, and 48 h post-exposure (hpe) to different concentrations of OA (50, 100, and 500 nM). Moreover, the expression of immune-system-related genes (CLT-6, FREP, HSP90, MT, and Cu/ZnSOD) was also measured. Results showed that ROS, MDA, and NO levels and LDH activity were enhanced after exposure to different concentrations of OA; however, both THC and GSH decreased between 24-48 hpe. The expression of immune-system-related genes was also assessed at different time points during the exposure period. Overall, our results suggest that exposure to OA had negative effects on immune system function, increased oxygenic stress, and disrupted metabolism of bay scallops.
ISSN
14203049
Language
English
URI
https://hdl.handle.net/10371/148869
DOI
https://doi.org/10.3390/molecules21091108
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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