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Anti-inflammatory effect of quercetin and galangin in LPS-stimulated RAW264.7 macrophages and DNCB-induced atopic dermatitis animal models
DC Field | Value | Language |
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dc.contributor.author | Le, Hae Nim | - |
dc.contributor.author | Shin, Seong Ah | - |
dc.contributor.author | Choo, Gang Sik | - |
dc.contributor.author | Kim, Hyeong Jin | - |
dc.contributor.author | Park, Young Seok | - |
dc.contributor.author | Kim, Byeong Soo | - |
dc.contributor.author | Kim, Sang Ki | - |
dc.contributor.author | Cho, Sung Dae | - |
dc.contributor.author | Nam, Jeong Seok | - |
dc.contributor.author | Choi, Chang Sun | - |
dc.contributor.author | Che, Jeong Hwan | - |
dc.contributor.author | Park, Byung Kwon | - |
dc.contributor.author | Jung, Ji Youn | - |
dc.creator | 조성대 | - |
dc.date.accessioned | 2019-04-25T01:21:17Z | - |
dc.date.available | 2020-04-05T01:21:17Z | - |
dc.date.created | 2019-03-20 | - |
dc.date.issued | 2018-02 | - |
dc.identifier.citation | International Journal of Molecular Medicine, Vol.41 No.2, pp.888-898 | - |
dc.identifier.issn | 1107-3756 | - |
dc.identifier.uri | https://hdl.handle.net/10371/149209 | - |
dc.description.abstract | Flavonols are compounds that have been shown to possess potent anti-inflammatory effects in cellular and animal models of inflammation. In the present study, the anti-inflammatory effects and mechanisms of two natural flavonols, quercetin and galangin, in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages were investigated. It was identified that quercetin and galangin markedly reduced the production of nitric oxide (NO), inducible NO synthase and interleukin-6, and the nuclear translocation of nuclear factor-kappa B (NF-kappa B). In addition, LPS-induced activation of extracellular signal-regulated kinase 1/2 (Erk1/2) and c-Jun N-terminal kinase (JNK) was suppressed by quercetin and galangin. Taken together, these data implied that NF-kappa B, Erk1/2 and JNK may be potential molecular targets of quercetin and galangin in an LPS-induced inflammatory response. Subsequently, the effects of oral administration of quercetin or galangin, either alone or in combination, in a 2,4-dinitrochlorobenzene-induced atopic dermatitis (AD) mouse model were investigated. As a result, measurements of ear thickness and the levels of serum immunoglobulin E, and histological analysis revealed that the two flavonols led to a decrease in inflammation, whereas, in combination, they were even more effective. These results suggested that quercetin and galangin may be promising therapeutic agents for AD. Additionally, their combination may be a novel therapeutic strategy for the prevention of AD. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | Demetrios A. Spandidos Ed. & Pub. | - |
dc.title | Anti-inflammatory effect of quercetin and galangin in LPS-stimulated RAW264.7 macrophages and DNCB-induced atopic dermatitis animal models | - |
dc.type | Article | - |
dc.identifier.doi | 10.3892/ijmm.2017.3296 | - |
dc.citation.journaltitle | International Journal of Molecular Medicine | - |
dc.identifier.wosid | 000423222200032 | - |
dc.identifier.scopusid | 2-s2.0-85040467710 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201800242 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A080405 | - |
dc.description.srnd | CITE_RATE:2.784 | - |
dc.description.srnd | FILENAME:C4_201802_Anti-inflammatory effects of quercetin and galangin in LPS-stimulated macrophages and DNCB-induced atopic dermatitis animal models_International Journal of Molecular Medicine.pdf | - |
dc.description.srnd | DEPT_NM:치의과학과 | - |
dc.description.srnd | EMAIL:efiwdsc@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | FILEURL:https://srnd.snu.ac.kr/eXrepEIR/fws/file/8b463a8b-205e-4eb2-87c0-743183d6ac81/link | - |
dc.citation.endpage | 898 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 888 | - |
dc.citation.volume | 41 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Cho, Sung Dae | - |
dc.identifier.srnd | T201800242 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | RAW 264.7 CELLS | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | INFLAMMATORY DISEASES | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | ENDOTOXIN-SHOCK | - |
dc.subject.keywordPlus | MAST-CELLS | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordAuthor | hydroxy group | - |
dc.subject.keywordAuthor | flavonol | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordAuthor | nuclear factor-kappa B | - |
dc.subject.keywordAuthor | mitogen-activated protein kinase | - |
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