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Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis
DC Field | Value | Language |
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dc.contributor.author | Yu, Hyun-Ju | - |
dc.contributor.author | Ahn, Chi-Hyun | - |
dc.contributor.author | Yang, In-Hyoung | - |
dc.contributor.author | Won, Dong-Hoon | - |
dc.contributor.author | Jin, Bohwan | - |
dc.contributor.author | Cho, Nam-Pyo | - |
dc.contributor.author | Hong, Seong Doo | - |
dc.contributor.author | Shin, Ji-Ae | - |
dc.contributor.author | Cho, Sung-Dae | - |
dc.creator | 조성대 | - |
dc.date.accessioned | 2019-04-25T01:21:46Z | - |
dc.date.available | 2020-04-05T01:21:46Z | - |
dc.date.created | 2019-03-29 | - |
dc.date.created | 2019-03-29 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.citation | Molecular Medicine Reports, Vol.17 No.4, pp.5258-5264 | - |
dc.identifier.issn | 1791-2997 | - |
dc.identifier.uri | https://hdl.handle.net/10371/149216 | - |
dc.description.abstract | Potentilla discolor has been used in traditional Chinese medicine for the treatment of hyperglycemia. However, the potential role of Potentilla discolor against cancer and its mode of action remain to be fully elucidated. The present study explored the apoptotic effect of methanol extract of Potentilla discolor (MEPD) in human mucoepidermoid carcinoma (MEC) cell lines of salivary glands. MEPD markedly suppressed the growth and induced apoptotic cell death in MC3 and YD15 cells. MEPD treatment significantly upregulated the expression of PUMA and reduced STAT3 phosphorylation. Overexpression of STAT3 partially recovered the growth of MEC cells inhibited by MEPD. In addition, dephosphorylation of STAT3 by cryptotanshinone (a potent STAT3 inhibitor) was sufficient to inhibit the growth of MEC cells and induce apoptosis via affecting PUMA protein. These results suggest that MEPD has a potential anticancer property via the STAT3/PUMA signaling axis in human MEC cells of salivary gland. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | Spandidos Publications | - |
dc.title | Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis | - |
dc.type | Article | - |
dc.identifier.doi | 10.3892/mmr.2018.8468 | - |
dc.citation.journaltitle | Molecular Medicine Reports | - |
dc.identifier.wosid | 000428672100049 | - |
dc.identifier.scopusid | 2-s2.0-85043227654 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201802474 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A080405 | - |
dc.description.srnd | CITE_RATE:1.922 | - |
dc.description.srnd | FILENAME:6_201804_Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3_PUMA signaling axis_Molecular Medicine Reports.pdf | - |
dc.description.srnd | DEPT_NM:치의과학과 | - |
dc.description.srnd | EMAIL:efiwdsc@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | FILEURL:https://srnd.snu.ac.kr/eXrepEIR/fws/file/f51e098f-b700-40fc-905f-a784f41fe7fa/link | - |
dc.citation.endpage | 5264 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 5258 | - |
dc.citation.volume | 17 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Hong, Seong Doo | - |
dc.contributor.affiliatedAuthor | Cho, Sung-Dae | - |
dc.identifier.srnd | T201802474 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | IMPATIENS-BALSAMINA L. | - |
dc.subject.keywordPlus | ORAL-CANCER CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | PUMA | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordPlus | NUTRACEUTICALS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | RESVERATROL | - |
dc.subject.keywordAuthor | Potentilla discolor | - |
dc.subject.keywordAuthor | mucoepidermoid carcinoma cell line | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | PUMA | - |
dc.subject.keywordAuthor | STAT3 | - |
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