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Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Silva, Gabriel | - |
dc.contributor.author | Marins, Mozart | - |
dc.contributor.author | Chaichanasak, Nadda | - |
dc.contributor.author | Yoon, Yongdae | - |
dc.contributor.author | Fachin, Ana Lucia | - |
dc.contributor.author | Pinhanelli, Vitor Caressato | - |
dc.contributor.author | Regasini, Luis Octavio | - |
dc.contributor.author | dos Santos, Mariana Bastos | - |
dc.contributor.author | Ayusso, Gabriela Miranda | - |
dc.contributor.author | Marques, Beatriz de Carvalho | - |
dc.contributor.author | Wu, Wells W. | - |
dc.contributor.author | Phue, Je-Nie | - |
dc.contributor.author | Shen, Rong-Fong | - |
dc.contributor.author | Baek, Seung Joon | - |
dc.creator | Baek Seung Joon | - |
dc.date.accessioned | 2019-04-25T01:24:10Z | - |
dc.date.available | 2020-04-05T01:24:10Z | - |
dc.date.created | 2019-08-02 | - |
dc.date.issued | 2018-08 | - |
dc.identifier.citation | PLoS ONE, Vol.13 No.8, p. e0202263 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://hdl.handle.net/10371/149344 | - |
dc.description.abstract | Naturally-occurring chalcones and synthetic chalcone analogues have been demonstrated to have many biological effects, including anti-inflammatory, anti-malarial, anti-fungal, and anti-oxidant/anti-cancerous activities. Compared to other chalcones, trans-chalcone exhibits superior inhibitory activity in cancer cell growth as shown via in vitro assays, and exerts anti-cancerous effects via the activation of the p53 tumor suppressor protein. Thus, characterization of the specific mechanisms, by which trans-chalcone activates p53, can aid development of new chemotherapeutic drugs that can be used individually or synergistically with other drugs. In this report, we found that trans-chalcone modulates many p53 target genes, HSP40 being the most induced gene in the RNA-Seq data using trans-chalcone-treated cells. CRM1 is also inhibited by trans-chalcone, resulting in the accumulation of p53 and other tumor suppressor proteins in the nucleus. Similar effects were seen using trans-chalcone derivatives. Overall, trans-chalcone could provide a strong foundation for the development of chalcone-based anti-cancer drugs. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | Public Library of Science | - |
dc.title | Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition | - |
dc.type | Article | - |
dc.identifier.doi | 10.1371/journal.pone.0202263 | - |
dc.citation.journaltitle | PLoS ONE | - |
dc.identifier.wosid | 000442282700020 | - |
dc.identifier.scopusid | 2-s2.0-85053756231 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201808767 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A080467 | - |
dc.description.srnd | CITE_RATE:2.766 | - |
dc.description.srnd | DEPT_NM:수의학과 | - |
dc.description.srnd | EMAIL:baeksj@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.citation.number | 8 | - |
dc.citation.startpage | e0202263 | - |
dc.citation.volume | 13 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Baek, Seung Joon | - |
dc.identifier.srnd | T201808767 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ACTIVATING TRANSCRIPTION FACTOR-3 | - |
dc.subject.keywordPlus | COLORECTAL-CANCER CELLS | - |
dc.subject.keywordPlus | NUCLEAR EXPORT | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | MDM2 | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | RESTORATION | - |
dc.subject.keywordPlus | BLOCKING | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | UBIQUITINATION | - |
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