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Dermatofibrosarcoma protuberans: A retrospective study of clinicopathologic features and related Akt/mTOR, STAT3, ERK, cyclin D1, and PD-L1 expression
DC Field | Value | Language |
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dc.contributor.author | Park, Sunyoung | - |
dc.contributor.author | Cho, Soyun | - |
dc.contributor.author | Kim, Minji | - |
dc.contributor.author | Park, Ji Ung | - |
dc.contributor.author | Jeong, Eui Cheol | - |
dc.contributor.author | Choi, Euno | - |
dc.contributor.author | Hwan, Jeong | - |
dc.contributor.author | Lee, Cheol | - |
dc.contributor.author | Chang, Mee Soo | - |
dc.creator | 조소연 | - |
dc.date.accessioned | 2019-04-25T01:52:09Z | - |
dc.date.available | 2020-04-05T01:52:09Z | - |
dc.date.created | 2019-06-19 | - |
dc.date.created | 2019-06-19 | - |
dc.date.issued | 2018-11 | - |
dc.identifier.citation | Journal of the American Academy of Dermatology, Vol.79 No.5, pp.843-852 | - |
dc.identifier.issn | 0190-9622 | - |
dc.identifier.uri | https://hdl.handle.net/10371/149762 | - |
dc.description.abstract | Background: Little is known regarding oncoproteins other than platelet-derived growth factor subunit B in dermatofibrosarcoma protuberans (DFSP). Moreover, the risk factors for worse prognosis are controversial. Objective: We sought to determine the clinicopathologic features and key factors for adverse outcome in DFSP, including the implication of expression of protein kinase B (Akt)/mammalian target of rapamycin (mTOR), signal transducer and activator of transcription 3 (STAT3), extracellular signal regulated kinase (ERK), cyclin D1, and programmed death ligand 1 (PD-L1). Methods: Clinicopathologic and immunohistochemical analyses were performed for 44 DFSPs having wide local excision and 92 dermatofibromas as controls. Results: Compared with the 35 nonrecurrent DFSPs, the 9 recurrent DFSPs exhibited larger tumor size, deeper invasion beyond the subcutis, and more diverse histologic subtype. The fibrosarcomatous subtype revealed frequent mitotic figures and a high cyclin D1-positive index. The 2 metastatic DFSPs (1 each of the fibrosarcomatous and myxoid subtypes) demonstrated 4 and 11 instances of local recurrence, respectively, as well as larger tumor size, deeper invasion beyond the subcutis, and high expression of cyclin D1. Expression of Akt/mTOR, STAT3, ERK, and PD-L1 ranged from none or low in the primary skin lesions to high in the corresponding metastatic sites. Akt/mTOR and ERK were expressed more frequently in DFSP than in dermatofibroma. Limitations: Lack of information on patients before hospital evaluation. Conclusion: Complex factors beyond fibrosarcomatous subtype may portend local recurrence or metastasis. Akt/mTOR, STAT3, ERK, and PD-L1 may be associated with development and/or progression of DFSP. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | Mosby Inc. | - |
dc.title | Dermatofibrosarcoma protuberans: A retrospective study of clinicopathologic features and related Akt/mTOR, STAT3, ERK, cyclin D1, and PD-L1 expression | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jaad.2018.05.016 | - |
dc.citation.journaltitle | Journal of the American Academy of Dermatology | - |
dc.identifier.wosid | 000447147700014 | - |
dc.identifier.scopusid | 2-s2.0-85053035133 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201811310 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A079501 | - |
dc.description.srnd | CITE_RATE:6.898 | - |
dc.description.srnd | FILENAME:DFSP JAAD 2018.pdf | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | EMAIL:sycho@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | FILEURL:https://srnd.snu.ac.kr/eXrepEIR/fws/file/c4eff3b6-99f7-4929-9aff-c4f8ab5d9adf/link | - |
dc.citation.endpage | 852 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 843 | - |
dc.citation.volume | 79 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Soyun | - |
dc.contributor.affiliatedAuthor | Chang, Mee Soo | - |
dc.identifier.srnd | T201811310 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | FIBROSARCOMATOUS TRANSFORMATION | - |
dc.subject.keywordPlus | FUSION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | EMPHASIS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordAuthor | Akt | - |
dc.subject.keywordAuthor | cyclin D1 | - |
dc.subject.keywordAuthor | dermatofibrosarcoma protuberans | - |
dc.subject.keywordAuthor | ERK | - |
dc.subject.keywordAuthor | metastasis | - |
dc.subject.keywordAuthor | mTOR | - |
dc.subject.keywordAuthor | PD-L1 | - |
dc.subject.keywordAuthor | recurrence | - |
dc.subject.keywordAuthor | STAT3 | - |
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