Publications
Detailed Information
Essential role of Polo-like kinase 1 (Plk1) oncogene in tumor growth and metastasis of tamoxifen-resistant breast cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Sung Baek | - |
dc.contributor.author | Im, Ji Hye | - |
dc.contributor.author | Yoon, Jeong-Hoon | - |
dc.contributor.author | Bui, Quyen Thu | - |
dc.contributor.author | Lim, Sung Chul | - |
dc.contributor.author | Song, Joon Myong | - |
dc.contributor.author | Shim, Yumi | - |
dc.contributor.author | Yun, Jieun | - |
dc.contributor.author | Hong, Janghee | - |
dc.contributor.author | Kang, Keon Wook | - |
dc.creator | 강건욱 | - |
dc.date.accessioned | 2019-04-25T01:53:14Z | - |
dc.date.available | 2020-04-05T01:53:14Z | - |
dc.date.created | 2019-03-29 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.citation | Molecular Cancer Therapeutics, Vol.17 No.4, pp.825-837 | - |
dc.identifier.issn | 1535-7163 | - |
dc.identifier.uri | https://hdl.handle.net/10371/149828 | - |
dc.description.abstract | The most common therapy for estrogen receptor-positive breast cancer is antihormone therapy, such as tamoxifen. However, acquisition of resistance to tamoxifen in one third of patients presents a serious clinical problem. Polo-like kinase 1 (Plk1) is a key oncogenic regulator of completion of G(2)-M phase of the cell cycle. We assessed Plk1 expression in five chemoresistant cancer cell types and found that Plk1 and its downstreamphosphatase Cdc25c were selectively overexpressed in tamoxifen-resistant MCF-7 (TAMR-MCF-7) breast cancer cells. Real-time monitoring of cell proliferation also showed that TAMR-MCF-7 cells were more sensitive to inhibition of cell proliferation by the ATP-competitive Plk1 inhibitor BI2536 than were the parent MCF-7 cells. Moreover, BI2536 suppressed expression of epithelial-mesenchymal transition marker proteins and 3D spheroid formation in TAMR-MCF-7 cells. Using TAMR-MCF-7 cell-implanted xenograft and spleen-liver metastasis models, we showed that BI2536 inhibited tumor growth and metastasis in vivo. Our results suggest that Plk1 could be a novel target for the treatment of tamoxifen-resistant breast cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | American Association for Cancer Research | - |
dc.title | Essential role of Polo-like kinase 1 (Plk1) oncogene in tumor growth and metastasis of tamoxifen-resistant breast cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.1158/1535-7163.MCT-17-0545 | - |
dc.citation.journaltitle | Molecular Cancer Therapeutics | - |
dc.identifier.wosid | 000429111900012 | - |
dc.identifier.scopusid | 2-s2.0-85048133100 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201814246 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A078837 | - |
dc.description.srnd | CITE_RATE:5.365 | - |
dc.description.srnd | DEPT_NM:약학과 | - |
dc.description.srnd | EMAIL:kwkang@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.citation.endpage | 837 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 825 | - |
dc.citation.volume | 17 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Song, Joon Myong | - |
dc.contributor.affiliatedAuthor | Kang, Keon Wook | - |
dc.identifier.srnd | T201814246 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | ESTROGEN-RECEPTOR | - |
dc.subject.keywordPlus | CELL-LINES | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | MODEL | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.