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Quinic acid-conjugated nanoparticles enhance drug delivery to solid tumors via interactions with endothelial selectins
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Xu, Jun | - |
dc.contributor.author | Lee, Steve Seung-Young | - |
dc.contributor.author | Seo, Howon | - |
dc.contributor.author | Pang, Liang | - |
dc.contributor.author | Jun, Yearin | - |
dc.contributor.author | Zhang, Ruo-Yu | - |
dc.contributor.author | Zhang, Zhong-Yin | - |
dc.contributor.author | Kim, Pilhan | - |
dc.contributor.author | Lee, Wooin | - |
dc.contributor.author | Kron, Stephen J. | - |
dc.contributor.author | Yeo, Yoon | - |
dc.creator | 이우인 | - |
dc.date.accessioned | 2019-04-25T02:09:48Z | - |
dc.date.available | 2020-04-05T02:09:48Z | - |
dc.date.created | 2019-08-21 | - |
dc.date.created | 2019-08-21 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.citation | Small, Vol.14 No.50, p. 1803601 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.uri | https://hdl.handle.net/10371/150445 | - |
dc.description.abstract | Current nanoparticle (NP) drug carriers mostly depend on the enhanced permeability and retention (EPR) effect for selective drug delivery to solid tumors. However, in the absence of a persistent EPR effect, the peritumoral endothelium can function as an access barrier to tumors and negatively affect the effectiveness of NPs. In recognition of the peritumoral endothelium as a potential barrier in drug delivery to tumors, poly(lactic-co-glycolic acid) (PLGA) NPs are modified with a quinic acid (QA) derivative, synthetic mimic of selectin ligands. QA-decorated NPs (QA-NP) interact with human umbilical vein endothelial cells expressing E-/P-selectins and induce transient increase in endothelial permeability to translocate across the layer. QA-NP reach selectin-upregulated tumors, achieving greater tumor accumulation and paclitaxel (PTX) delivery than polyethylene glycol-decorated NPs (PEG-NP). PTX-loaded QA-NP show greater anticancer efficacy than Taxol or PTX-loaded PEG-NP at the equivalent PTX dose in different animal models and dosing regimens. Repeated dosing of PTX-loaded QA-NP for two weeks results in complete tumor remission in 40-60% of MDA-MB-231 tumor-bearing mice, while those receiving control treatments succumb to death. QA-NP can exploit the interaction with selectin-expressing peritumoral endothelium and deliver anticancer drugs to tumors to a greater extent than the level currently possible with the EPR effect. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | Wiley - V C H Verlag GmbbH & Co. | - |
dc.title | Quinic acid-conjugated nanoparticles enhance drug delivery to solid tumors via interactions with endothelial selectins | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/smll.201803601 | - |
dc.citation.journaltitle | Small | - |
dc.identifier.wosid | 000453627100020 | - |
dc.identifier.scopusid | 2-s2.0-85056307066 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201829974 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A079739 | - |
dc.description.srnd | CITE_RATE:9.598 | - |
dc.description.srnd | DEPT_NM:제약학과 | - |
dc.description.srnd | EMAIL:wooin.lee@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.citation.number | 50 | - |
dc.citation.startpage | 1803601 | - |
dc.citation.volume | 14 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, Wooin | - |
dc.identifier.srnd | T201829974 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ACCELERATED BLOOD CLEARANCE | - |
dc.subject.keywordPlus | CELL-ADHESION MOLECULES | - |
dc.subject.keywordPlus | P-SELECTIN | - |
dc.subject.keywordPlus | PEGYLATED LIPOSOMES | - |
dc.subject.keywordPlus | SIALYL LEWIS(X) | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | TRANSENDOTHELIAL MIGRATION | - |
dc.subject.keywordPlus | METASTATIC TUMORS | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | polymeric nanoparticles | - |
dc.subject.keywordAuthor | quinic acid | - |
dc.subject.keywordAuthor | selectin | - |
dc.subject.keywordAuthor | tumor microenvironment | - |
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