S-Space College of Medicine/School of Medicine (의과대학/대학원) Otorhinolaryngology (이비인후과학전공) Journal Papers (저널논문_이비인후과학전공)
Suppression of accelerated tumor growth in surgical wounds by celecoxib and indomethacin
- Roh, Jong-Lyel; Sung, Myung-Whun; Kim, Kwang Hyun
- Issue Date
- John Wiley & Sons
- Head Neck. 2005 Apr;27(4):326-32.
- Animals; Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use; Carcinoma/pathology/*prevention & control; Carcinoma, Squamous Cell/pathology/*prevention & control; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors/*therapeutic use; Disease Models, Animal; Indomethacin/*therapeutic use; Male; Melanoma/pathology/*prevention & control; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred Strains; Muscle, Skeletal/*surgery; Neoplasm Recurrence, Local/prevention & control; Neoplasm Seeding; Neoplasm Transplantation; Peroxidases/antagonists & inhibitors; Prostaglandin-Endoperoxide Synthases/drug effects; Pyrazoles/*therapeutic use; Sulfonamides/*therapeutic use
- BACKGROUND: Tumor growth is accelerated in surgical wounds. However, few experiments seeking to prevent such accelerated tumor growth have been performed. METHODS: We created surgical wounds in three syngeneic mice for the implantation of three murine cancer cell lines, SCC VII, CT-26, and B16F10. The tumor growth in the wound group was compared with that in non-wound-control mice. Celecoxib or indomethacin was administered to the mice that had tumor implanted into the surgical wound to observe the tumor-suppressive effect. RESULTS: The surgical wounds promoted tumor growth with different degrees, depending on the type of tumor. Such an accelerated tumor growth did not seem to be affected by cyclooxygenase-2 expression of tumors per se, but its mechanism needs to be explained by further studies. Celecoxib and indomethacin had a significant inhibitory effect on the tumor growth in the surgical wound. This suppressive effect is most obvious when celecoxib is administered daily from 1 day before surgical wounding and tumor implantation. CONCLUSION: Our results can justify that the preventive use of celecoxib in patients in whom local recurrence by tumor contamination is predicted.
- 1043-3074 (Print)
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