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Outcomes of hepatic resection for a single large hepatocellular carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Yong Beom | - |
dc.contributor.author | Lee, Kuhn Uk | - |
dc.contributor.author | Lee, Hae Won | - |
dc.contributor.author | Cho, Eung-Ho | - |
dc.contributor.author | Yang, Sung-Hoon | - |
dc.contributor.author | Cho, Jai Young | - |
dc.contributor.author | Yi, Nam-Joon | - |
dc.contributor.author | Suh, Kyung-Suk | - |
dc.date.accessioned | 2009-11-25T04:15:45Z | - |
dc.date.available | 2009-11-25T04:15:45Z | - |
dc.date.issued | 2007-03-09 | - |
dc.identifier.citation | World J Surg. 2007 Apr;31(4):795-801. | en |
dc.identifier.issn | 0364-2313 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17345125 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15216 | - |
dc.description.abstract | BACKGROUND: The proper role of surgical resection, given the various treatment modalities available, needs to be further clarified in patients with a single large hepatocellular carcinoma (HCC). To evaluate the role of surgical resection in this group of patients, we studied the long-term outcomes of patients that received hepatic resection for a single large (> 5-10 cm in diameter) HCC. METHODS: The clinicopathologic data and long-term outcomes of 61 patients with a single large HCC (> 5-10 cm in diameter; L group) were compared with those of 169 patients with a single small HCC (< or = 5 cm; S group). Prognostic factors were evaluated by univariate and multivariate analysis. RESULTS: Operative mortality rates were low in both groups (0.6% in group S and 1.6% in group L), and the incidence of postoperative hepatic failure was rare even in group L (1.6%). The cumulative 5-year overall survival rate in group S was 59.0%, whereas in group L it was 52.9% (p = 0.385), and the corresponding cumulative 5-year disease-free survival rates were 44.1% and 31.7%, respectively (p = 0.063). Child class B was found to predict poor overall and disease-free survival by multivariate analysis versus Child class A in both groups. The presence of microvascular invasion was also identified as a significant prognostic factor, but it only affected disease-free survival in the two groups. CONCLUSIONS: Single large HCCs do not require a large extent of hepatic resection and the associated increased risk of postoperative liver failure. The long-term survival of patients with a single large HCC is as good as that of patients with a single small HCC. We conclude that hepatic resection is a safe and effective therapy for single large HCCs. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Carcinoma, Hepatocellular/mortality/*surgery | en |
dc.subject | Disease-Free Survival | en |
dc.subject | Female | en |
dc.subject | Hepatectomy/*methods | en |
dc.subject | Humans | en |
dc.subject | Liver Neoplasms/mortality/*surgery | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Multivariate Analysis | en |
dc.subject | Neoplasm Recurrence, Local | en |
dc.subject | Postoperative Complications | en |
dc.subject | Prognosis | en |
dc.subject | Proportional Hazards Models | en |
dc.subject | Survival Rate | en |
dc.subject | Treatment Outcome | en |
dc.title | Outcomes of hepatic resection for a single large hepatocellular carcinoma | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 조용범 | - |
dc.contributor.AlternativeAuthor | 이건욱 | - |
dc.contributor.AlternativeAuthor | 이해원 | - |
dc.contributor.AlternativeAuthor | 조응호 | - |
dc.contributor.AlternativeAuthor | 양성훈 | - |
dc.contributor.AlternativeAuthor | 조재영 | - |
dc.contributor.AlternativeAuthor | 이남준 | - |
dc.contributor.AlternativeAuthor | 서경석 | - |
dc.identifier.doi | 10.1007/s00268-006-0359-z | - |
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