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Memantine reduces striatal cell death with decreasing calpain level in 3-nitropropionic model of Huntington's disease
Cited 41 time in
Web of Science
Cited 44 time in Scopus
- Authors
- Issue Date
- 2006-09-09
- Publisher
- Elsevier
- Citation
- Brain Res. 2006 Nov 6;1118(1):199-207. Epub 2006 Sep 7.
- Keywords
- Animals ; Apoptosis Regulatory Proteins/drug effects/metabolism ; Calpain/*drug effects/metabolism ; Cell Death/drug effects/physiology ; Corpus Striatum/*drug effects/pathology/physiopathology ; Disease Models, Animal ; Down-Regulation/drug effects/physiology ; Excitatory Amino Acid Antagonists/pharmacology/therapeutic use ; Huntington Disease/*drug therapy/metabolism/physiopathology ; Male ; Memantine/*pharmacology/therapeutic use ; Nerve Degeneration/*drug therapy/physiopathology/prevention & control ; Nerve Tissue Proteins/drug effects/metabolism ; Neurons/*drug effects/metabolism/pathology ; Neuroprotective Agents/pharmacology ; Neurotoxins ; Nitro Compounds ; Nuclear Proteins/drug effects/metabolism ; Peptide Fragments/drug effects/metabolism ; Propionic Acids ; Rats ; Rats, Sprague-Dawley
- Abstract
- Huntington's disease has an increase in the activated calpain, which is enhanced by the NMDA receptor activation. We investigated the neuroprotective effect of memantine in 3-nitropropionic acid (3NP)-induced striatal degeneration model. Either memantine (20 mg/kg/day) or PBS was intraperitoneally administered for five days with 3NP continuous infusion. In the memantine-treated group, the striatal lesion volume, the number of TUNEL+ cells, and Fluoro-Jade C+ degenerating neurons were all decreased. Memantine increased Bcl-xl and decreased Bax level. Memantine also exerted an inhibitory effect on the micro-calpain level and decreased the huntingtin proteolytic fragments. Those rats treated with memantine showed less degree of weight loss at 5 days. Subsequently, memantine was found to have neuroprotective effects and save striatal cells with decreasing calpain levels in the 3NP model of Huntington's disease.
- ISSN
- 0006-8993 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16959224
https://hdl.handle.net/10371/15282
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