Publications
Detailed Information
Effective local control of prostate cancer by intratumoral injection of (166)Ho-chitosan complex (DW-166HC) in rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwak, Cheol | - |
dc.contributor.author | Hong, Sung Kyu | - |
dc.contributor.author | Seong, Seung Kyoo | - |
dc.contributor.author | Ryu, Jei Man | - |
dc.contributor.author | Park, Moon Soo | - |
dc.contributor.author | Lee, Sang Eun | - |
dc.date.accessioned | 2009-11-25T05:19:11Z | - |
dc.date.available | 2009-11-25T05:19:11Z | - |
dc.date.issued | 2005-09-01 | - |
dc.identifier.citation | Eur J Nucl Med Mol Imaging. 2005 Dec;32(12):1400-5. Epub 2005 Aug 31. | en |
dc.identifier.issn | 1619-7070 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16133378 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15288 | - |
dc.description.abstract | PURPOSE: The aim of this study was to evaluate the therapeutic effect and morphological alterations resulting from (166)Ho-chitosan complex (DW-166HC) in an animal model of prostate cancer. METHODS: First, in a subcutaneous tumor model, 80 rats were randomly divided into four groups (n=20 in each group), and intratumoral injections of 0.05 ml (normal saline in group 1,( 165)Ho-chitosan complex solution in group 2, DW-166HC solution (10 mCi) in group 3, and DW-166HC solution (20 mCi) in group 4) were performed when the tumor measured approximately 1 cm along its long axis in each group. Further, in an orthotopic tumor model, 40 rats were similarly randomly divided into four groups (n=10 in each group), and intraprostatic injections of 0.05 ml [PBS in group 1,( 165)Ho-chitosan complex solution in group 2, DW-166HC solution (0.5 mCi) in group 3 and DW-166HC solution (1 mCi) in group 4] were performed at 1 week after implantation of the AIT cell line in the ventral prostate. RESULTS: In the subcutaneous tumor model, mean tumor weights of groups 3 and 4 were significantly lower than those of groups 1 and 2 at 2 and 4 weeks post injection (p<0.05). At 2 and 4 weeks after injection in the orthotopic tumor model, the mean weights of the prostate, including tumor, in groups 3 and 4 were also significantly lower than those in groups 1 and 2 (p<0.05). No adverse injury was seen in adjacent organs at histopathologic examination. CONCLUSION: Intratumoral injection of the beta-emitting radionuclide (166)Ho as a form of complex solution with chitosan appears to be a promising alternative therapeutic modality for the local control of prostate cancer. | en |
dc.language.iso | en | en |
dc.publisher | Springer International | en |
dc.subject | Animals | en |
dc.subject | Body Weight/radiation effects | en |
dc.subject | Chitin/administration & dosage/adverse effects/*analogs & derivatives | en |
dc.subject | Holmium/*administration & dosage/adverse effects | en |
dc.subject | Injections, Intralesional/*methods | en |
dc.subject | Male | en |
dc.subject | Organometallic Compounds/*administration & dosage/adverse effects | en |
dc.subject | Prostatic Neoplasms/*pathology/*radiotherapy | en |
dc.subject | Radioisotopes/*administration & dosage/adverse effects | en |
dc.subject | Radiopharmaceuticals/administration & dosage/adverse effects | en |
dc.subject | Rats | en |
dc.subject | Survival Rate | en |
dc.subject | Treatment Outcome | en |
dc.title | Effective local control of prostate cancer by intratumoral injection of (166)Ho-chitosan complex (DW-166HC) in rats | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 곽철 | - |
dc.contributor.AlternativeAuthor | 홍성규 | - |
dc.contributor.AlternativeAuthor | 성승규 | - |
dc.contributor.AlternativeAuthor | 류재만 | - |
dc.contributor.AlternativeAuthor | 박문수 | - |
dc.contributor.AlternativeAuthor | 이상은 | - |
dc.identifier.doi | 10.1007/s00259-005-1892-y | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.