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Recurrence and prognostic factors of ampullary carcinoma after radical resection: comparison with distal extrahepatic cholangiocarcinoma
DC Field | Value | Language |
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dc.contributor.author | Woo, Sang Myung | - |
dc.contributor.author | Ryu, Ji Kon | - |
dc.contributor.author | Lee, Sang Hyub | - |
dc.contributor.author | Yoo, Ji Won | - |
dc.contributor.author | Park, Joo Kyung | - |
dc.contributor.author | Kim, Yong-Tae | - |
dc.contributor.author | Jang, Jin-Young | - |
dc.contributor.author | Kim, Sun-Whe | - |
dc.contributor.author | Kang, Gyeong Hoon | - |
dc.contributor.author | Yoon, Yong Bum | - |
dc.date.accessioned | 2009-11-25T06:09:51Z | - |
dc.date.available | 2009-11-25T06:09:51Z | - |
dc.date.issued | 2007-08-22 | - |
dc.identifier.citation | Ann Surg Oncol. 2007 Nov;14(11):3195-201. Epub 2007 Aug 19 | en |
dc.identifier.issn | 1534-4681 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17710498 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15304 | - |
dc.description.abstract | BACKGROUND: Ampullary carcinoma is often considered to have a better prognosis than distal extrahepatic cholangiocarcinoma. However, studies that directly compare the recurrence and histopathological features between the two groups are rare. METHODS: Clinicopathologic factors and the long-term outcomes of 163 patients with ampullary carcinoma after radical resection were retrospectively evaluated and compared with those of 91 patients with distal extrahepatic cholangiocarcinoma. RESULTS: Among the 163 ampullary carcinomas, T1 stage, well-differentiated tumors and perineural invasion were 45 (28%), 73 (45%), and 23 (14%), respectively, whereas, only five (6%) were T1 stage, 15 (17%) were well differentiated, and 63 (69%) showed perineural invasion (p < 0.001, for all) in distal extrahepatic cholangiocarcinomas. More patients with distal extrahepatic cholangiocarcinoma had liver metastasis than ampullary carcinoma (24% vs. 10%, p = 0.004). Multivariate analysis identified venous invasion and perineural invasion as risk factors for recurrence of ampullary carcinoma after radical resection. Only lymph node involvement was identified as a risk factor for recurrence of distal extrahepatic cholangiocarcinoma by multivariate analysis. Overall five-year survival of patients with ampullary cancer was higher than that of patients with distal extrahepatic cholangiocarcinoma (68% vs. 54%; p = 0.033). In patients without lymph node metastasis, a significant difference in survival was also observed between the two groups (p = 0.049). CONCLUSION: Earlier diagnosis and the less frequent occurrence of pathological factors associated with tumor invasiveness in ampullary carcinoma than in distal extrahepatic cholangiocarcinoma may explain its association with a better prognosis. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Ampulla of Vater/*pathology/surgery | en |
dc.subject | Bile Ducts, Extrahepatic/*pathology/surgery | en |
dc.subject | Cholangiocarcinoma/*pathology/surgery | en |
dc.subject | Common Bile Duct Neoplasms/*pathology/surgery | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Neoplasm Recurrence, Local/*diagnosis | en |
dc.subject | Pancreaticoduodenectomy | en |
dc.subject | Prognosis | en |
dc.subject | Retrospective Studies | en |
dc.subject | Survival Rate | en |
dc.subject | Treatment Outcome | en |
dc.title | Recurrence and prognostic factors of ampullary carcinoma after radical resection: comparison with distal extrahepatic cholangiocarcinoma | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 우상명 | - |
dc.contributor.AlternativeAuthor | 류지곤 | - |
dc.contributor.AlternativeAuthor | 이상협 | - |
dc.contributor.AlternativeAuthor | 유지원 | - |
dc.contributor.AlternativeAuthor | 박주경 | - |
dc.contributor.AlternativeAuthor | 김용태 | - |
dc.contributor.AlternativeAuthor | 장진영 | - |
dc.contributor.AlternativeAuthor | 김선혜 | - |
dc.contributor.AlternativeAuthor | 강경훈 | - |
dc.contributor.AlternativeAuthor | 윤용범 | - |
dc.identifier.doi | 10.1245/s10434-007-9537-y | - |
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