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Effects of antenatal corticosteroids in twin neonates with late preterm birth (ACTWIN [Antenatal Corticosteroids in TWIN late preterm neonates] trial): study protocol for a randomized controlled trial
DC Field | Value | Language |
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dc.contributor.author | Hong, Subeen | - |
dc.contributor.author | Lee, Seung Mi | - |
dc.contributor.author | Kwak, Dong Wook | - |
dc.contributor.author | Lee, Joongyub | - |
dc.contributor.author | Kim, So Yeon | - |
dc.contributor.author | Oh, Jeong Won | - |
dc.contributor.author | Oh, Sohee | - |
dc.contributor.author | Park, Chan-Wook | - |
dc.contributor.author | Park, Joong Shin | - |
dc.contributor.author | Chung, Jin Hoon | - |
dc.contributor.author | Jun, Jong Kwan | - |
dc.date.accessioned | 2019-05-10T01:17:53Z | - |
dc.date.available | 2019-05-10T10:19:23Z | - |
dc.date.issued | 2019-04-03 | - |
dc.identifier.citation | BMC Pregnancy and Childbirth, 19(1):114 | ko_KR |
dc.identifier.issn | 1471-2393 | - |
dc.identifier.uri | https://hdl.handle.net/10371/153141 | - |
dc.description.abstract | Background
Antenatal corticosteroids have been proven to prevent adverse outcomes including respiratory morbidities in preterm neonates before 34 weeks of gestation. Recently, it has been suggested that antenatal corticosteroids may also be effective in singleton late preterm pregnancies, and guidelines recommend the use of corticosteroids in singleton pregnant women who are at risk for late preterm birth. On the contrary, there is a paucity of information regarding the effectiveness of corticosteroids in twin neonates with late preterm birth. This study aims to determine the effectiveness of antenatal corticosteroids in late preterm twin neonates. Methods In this multicentre randomized controlled trial, women who are at risk for late preterm birth will be enrolled at 34 0/7 to 36 5/7 weeks of gestation. The participants will be randomly assigned to receive antenatal corticosteroids (betamethasone 12 mg, 3 mL intramuscularly [IM]) or placebo (normal saline 3 mL IM). The perinatal outcomes will be compared between the two groups of cases. The primary outcome is severe respiratory complications (the use of continuous positive airway pressure or high-flow nasal cannula for at least 12 h, supplemental oxygen administration with a fraction of oxygen 0.3 or more for at least 24 h, mechanical ventilation, or extracorporeal membranes oxygenation) or perinatal death within the first 72 h of delivery. The secondary outcomes are neonatal mortality and/or other neonatal morbidities. Discussion This study will be the first randomized controlled trial that evaluates the effectiveness of antenatal corticosteroids in late preterm twin neonates. Trial registration NCT03547791 (ClinicalTrials.gov), first submitted date: March 29, 2018, first posted date: June 6, 2018 (retrospectively registered). | ko_KR |
dc.description.sponsorship | This study was supported by a grant from the SNUH research fund(2018-1322) and the Korean Society of Maternal Fetal Medicine Research Fund. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Antenatal corticosteroids | ko_KR |
dc.subject | Late preterm birth | ko_KR |
dc.subject | Twin pregnancies | ko_KR |
dc.subject | Respiratory morbidity | ko_KR |
dc.subject | Randomized | ko_KR |
dc.subject | controlled tria | ko_KR |
dc.title | Effects of antenatal corticosteroids in twin neonates with late preterm birth (ACTWIN [Antenatal Corticosteroids in TWIN late preterm neonates] trial): study protocol for a randomized controlled trial | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 홍수빈 | - |
dc.contributor.AlternativeAuthor | 이승미 | - |
dc.contributor.AlternativeAuthor | 곽동욱 | - |
dc.contributor.AlternativeAuthor | 이중엽 | - |
dc.contributor.AlternativeAuthor | 김소연 | - |
dc.contributor.AlternativeAuthor | 오정원 | - |
dc.contributor.AlternativeAuthor | 오소희 | - |
dc.contributor.AlternativeAuthor | 박찬욱 | - |
dc.contributor.AlternativeAuthor | 박중신 | - |
dc.contributor.AlternativeAuthor | 정진훈 | - |
dc.contributor.AlternativeAuthor | 전종관 | - |
dc.identifier.doi | 10.1186/s12884-019-2235-5 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2019-04-07T03:20:48Z | - |
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