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Prenatal selective serotonin reuptake inhibitor (SSRI) exposure induces working memory and social recognition deficits by disrupting inhibitory synaptic networks in male mice
DC Field | Value | Language |
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dc.contributor.author | Yu, Weonjin | - |
dc.contributor.author | Yen, Yi-Chun | - |
dc.contributor.author | Lee, Young-Hwan | - |
dc.contributor.author | Tan, Shawn | - |
dc.contributor.author | Xiao, Yixin | - |
dc.contributor.author | Lokman, Hidayat | - |
dc.contributor.author | Ting, Audrey Khoo Tze Ting | - |
dc.contributor.author | Ganegala, Hasini | - |
dc.contributor.author | Kwon, Taejoon | - |
dc.contributor.author | Ho, Won-Kyung | - |
dc.contributor.author | Je, H. Shawn | - |
dc.date.accessioned | 2019-05-10T01:23:24Z | - |
dc.date.available | 2019-05-10T10:24:52Z | - |
dc.date.issued | 2019-04-01 | - |
dc.identifier.citation | Molecular Brain, 12(1):29 | ko_KR |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | https://hdl.handle.net/10371/153142 | - |
dc.description.abstract | Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed antidepressant drugs in pregnant women. Infants born following prenatal exposure to SSRIs have a higher risk for behavioral abnormalities, however, the underlying mechanisms remains unknown. Therefore, we examined the effects of prenatal fluoxetine, the most commonly prescribed SSRI, in mice. Intriguingly, chronic in utero fluoxetine treatment impaired working memory and social novelty recognition in adult males. In the medial prefrontal cortex (mPFC), a key region regulating these behaviors, we found augmented spontaneous inhibitory synaptic transmission onto the layer 5 pyramidal neurons. Fast-spiking interneurons in mPFC exhibited enhanced intrinsic excitability and serotonin-induced excitability due to upregulated serotonin (5-HT) 2A receptor (5-HT2AR) signaling. More importantly, the behavioral deficits in prenatal fluoxetine treated mice were reversed by the application of a 5-HT2AR antagonist. Taken together, our findings suggest that alterations in inhibitory neuronal modulation are responsible for the behavioral alterations following prenatal exposure to SSRIs. | ko_KR |
dc.description.sponsorship | This work was supported by Singapore Ministry of Education (MOE) Academic Research Fund (MOE2012-T2–1-021, MOE2014-T2–2-071), National Medical Research Council Individual Research Grant (NMRC/CBRG/0075/2014 and NMRC/OFIRG/0050/2017) and Translational Clinical Research Programme in Parkinsons Disease (NMRC/TCR/013-NNI/2014), A*Star Translational Collaborative Research Partnership Grant (TCRP, 13/1/96/688), National Research Foundation (NRF-CRP17–2017-04), Duke-NUS Signature Research Program Block Grant (all to H.S.J.), and a Khoo Postdoctoral Fellowship Award (Duke-NUS-KPFA/2017/0016, to S. T.). T.K. was supported by Basic Science Research Program via the National Research Foundation of Korea (NRF-2016R1C1B2009302) and the UNIST block grant (1.170009.01). | ko_KR |
dc.language.iso | en | ko_KR |
dc.subject | Prenatal | ko_KR |
dc.subject | Serotonin (5-HT) | ko_KR |
dc.subject | Selective serotonin reuptake inhibitor | ko_KR |
dc.subject | SSRI | ko_KR |
dc.subject | Fluoxetine | ko_KR |
dc.subject | Working memory | ko_KR |
dc.subject | Social recognition | ko_KR |
dc.subject | Serotonin 2A receptor (5-HT2AR) | ko_KR |
dc.title | Prenatal selective serotonin reuptake inhibitor (SSRI) exposure induces working memory and social recognition deficits by disrupting inhibitory synaptic networks in male mice | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이영환 | - |
dc.contributor.AlternativeAuthor | 권태준 | - |
dc.contributor.AlternativeAuthor | 호원경 | - |
dc.identifier.doi | 10.1186/s13041-019-0452-5 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2019-04-07T03:20:57Z | - |
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