Publications
Detailed Information
Outcomes of non-high grade serous carcinoma after neoadjuvant chemotherapy for advanced-stage ovarian cancer: a Korean gynecologic oncology group study (OV 1708)
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Young Shin | - |
dc.contributor.author | Park, Sang-Yoon | - |
dc.contributor.author | Lee, Jung-Yun | - |
dc.contributor.author | Park, Jeong-Yeol | - |
dc.contributor.author | Lee, Jeong-Won | - |
dc.contributor.author | Kim, Hee Seung | - |
dc.contributor.author | Suh, Dong Soo | - |
dc.contributor.author | Kim, Yun Hwan | - |
dc.contributor.author | Lee, Jong-Min | - |
dc.contributor.author | Kim, Miseon | - |
dc.contributor.author | Choi, Min Chul | - |
dc.contributor.author | Shim, Seung-Hyuk | - |
dc.contributor.author | Lee, Keun Ho | - |
dc.contributor.author | Song, Taejong | - |
dc.contributor.author | Hong, Jin Hwa | - |
dc.contributor.author | Lee, Won Moo | - |
dc.contributor.author | Lee, Banghyun | - |
dc.contributor.author | Lee, In Ho | - |
dc.date.accessioned | 2019-05-10T03:57:14Z | - |
dc.date.available | 2019-05-10T12:58:05Z | - |
dc.date.issued | 2019-04-11 | - |
dc.identifier.citation | BMC Cancer, 19(1):341 | ko_KR |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.uri | 10.1186/s12885-019-5514-7 | - |
dc.identifier.uri | https://hdl.handle.net/10371/153150 | - |
dc.description.abstract | Background
Outcomes of patients with ovarian high-grade serous carcinoma (HGSC) treated with neoadjuvant chemotherapy (NAC) have been widely studied, but there is limited information on the outcomes of patients with non-HGSC. This study aimed to evaluate the outcomes of NAC in non-HGSC patients with advanced-stage ovarian cancer. Methods We conducted a retrospective cohort study of patients who underwent NAC for advanced stage non-HGSC between 2002 and 2017 in 17 institutions. Demographics, surgical outcomes, and survival rates were evaluated according to histological subtypes. Results A total of 154 patients were included in this study, comprising 20 cases (13.0%) of mucinous adenocarcinoma, 31 cases (20.1%) of endometrioid adenocarcinoma, 28 (18.2%) cases of clear cell carcinoma, 29 (18.8%) cases of low-grade serous carcinoma and 12 cases (7.8%) of carcinosarcoma. Complete remission/partial remission after the third cycle of NAC was achieved in 100 (64.9%) patients and optimal debulking surgery (residual disease ≤1 cm) at interval debulking surgery was achieved in 103 (66.9%) patients. The most common reason for performing NAC was high tumor burden (n = 106, 68.8%). The median progression-free survival (PFS) was 14.3 months and median overall survival (OS) was 52.9 months. In multivariate analyses, mucinous and clear cell carcinoma were negative prognostic factors for both PFS (p = 0.007 and p = 0.017, respectively) and OS (p = 0.002 and p = 0.013, respectively). Conclusions In this study, poor survival outcomes were observed in patients with mucinous and clear cell carcinoma undergoing NAC. Different treatment strategies are urgently required to improve survival outcomes for this disease subset. | ko_KR |
dc.description.sponsorship | This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning (2017M3A9E8029714) and SHINPOONG PHARM.CO., LTD. The sponsors played no role in the study design, data collection, or analysis, or decision to submit the article for publication. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Ovarian neoplasms | ko_KR |
dc.subject | Histologic subtype | ko_KR |
dc.subject | Neoadjuvant therapy | ko_KR |
dc.subject | Non-high grade serous carcinoma | ko_KR |
dc.subject | Survival | ko_KR |
dc.title | Outcomes of non-high grade serous carcinoma after neoadjuvant chemotherapy for advanced-stage ovarian cancer: a Korean gynecologic oncology group study (OV 1708) | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 정영신 | - |
dc.contributor.AlternativeAuthor | 박상윤 | - |
dc.contributor.AlternativeAuthor | 이정윤 | - |
dc.contributor.AlternativeAuthor | 박정열 | - |
dc.contributor.AlternativeAuthor | 이정원 | - |
dc.contributor.AlternativeAuthor | 김희승 | - |
dc.contributor.AlternativeAuthor | 서동수 | - |
dc.contributor.AlternativeAuthor | 김윤환 | - |
dc.contributor.AlternativeAuthor | 이종민 | - |
dc.contributor.AlternativeAuthor | 김미선 | - |
dc.contributor.AlternativeAuthor | 최민철 | - |
dc.contributor.AlternativeAuthor | 심승혁 | - |
dc.contributor.AlternativeAuthor | 이근호 | - |
dc.contributor.AlternativeAuthor | 송태종 | - |
dc.contributor.AlternativeAuthor | 홍진화 | - |
dc.contributor.AlternativeAuthor | 이원무 | - |
dc.contributor.AlternativeAuthor | 이방현 | - |
dc.contributor.AlternativeAuthor | 이인호 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2019-04-14T03:33:47Z | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.