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Respiratory severity score as a predictive factor for severe bronchopulmonary dysplasia or death in extremely preterm infants

Cited 4 time in Web of Science Cited 2 time in Scopus
Authors
Jung, Young Hwa; Jang, Jinhee; Kim, Han-Suk; Shin, Seung Han; Choi, Chang Won; Kim, Ee-Kyung; Kim, Beyong Il
Issue Date
2019-04-23
Publisher
BioMed Central
Citation
BMC Pediatrics, 19(1):121
Keywords
Bronchopulmonary dysplasiaRespiratory severity scoreVentilatory supportPremature infantNeonatal intensive care
Abstract
Background
Despite significant advances in neonatology, bronchopulmonary dysplasia (BPD) remains the most common cause of serious morbidity and mortality in premature infants. The aim of the present study was to determine associations between the respiratory severity score (RSS) with death or BPD in premature infants.

Methods
This was a retrospective study conducted between January 2010 and December 2014. We enrolled preterm infants with a gestational age of less than 28 weeks who were supported by mechanical ventilation for more than a week during the first 4 weeks of life. We collected the RSS scores on day of life 2, 7, 14, 21 and 28. The correlations between postnatal RSSs and death or severe BPD were analyzed using multivariate logistic regression.

Results
Of the 138 eligible infants, 66 infants (47.8%) either died or developed severe BPD. The RSS cut-off values for predicting severe BPD or death were 3.0 for postnatal day (PND) 14 with an odds ratio (OR) of 11.265 (p = 0.0006, 95% confidence interval (CI), 2.842 to 44.646), 3.6 for PND 21 with an OR of 15.162 (p = 0.0003, 95% CI, 3.467 to 66.316), and 3.24 for PND 28 with an OR of 10.713 (p = 0.0005, 95% CI, 2.825 to 40.630).

Conclusion
Strong correlations were observed between the RSSs on PND 14, 21, and 28 and death or subsequent severe BPD. The RSS could provide a simple estimate of severe BPD or death., Further research with a larger study population is necessary to validate the usefulness of the RSS for predicting severe BPD or death.
ISSN
1471-2431
Language
Korean
URI
http://hdl.handle.net/10371/153814
DOI
https://doi.org/10.1186/s12887-019-1492-9
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College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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