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Clinical characteristics and prognosis of pediatric hepatocellular carcinoma

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dc.contributor.authorYu, Seung-Beom-
dc.contributor.authorKim, Hyun-Young-
dc.contributor.authorEo, Hong-
dc.contributor.authorWon, Jae-Kyung-
dc.contributor.authorJung, Sung-Eun-
dc.contributor.authorPark, Kwi-Won-
dc.contributor.authorKim, Woo-Ki-
dc.date.accessioned2009-11-25T23:41:18Z-
dc.date.available2009-11-25T23:41:18Z-
dc.date.issued2005-12-22-
dc.identifier.citationWorld J Surg. 2006 Jan;30(1):43-50en
dc.identifier.issn0364-2313 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16369702-
dc.identifier.urihttps://hdl.handle.net/10371/15509-
dc.description.abstractINTRODUCTION: Hepatocellular carcinoma (HCC) is a rare pediatric malignancy that is usually advanced at diagnosis, with a relatively poor prognosis. Extensive treatment, including complete tumor resection, is believed to be necessary for cure. This study was performed to analyze treatment results and to search for prognostic factors of pediatric HCC. METHODS: Between March 1982 and February 2004 a total of 16 children had been diagnosed as having HCC in our institution, and a retrospective analysis was performed. RESULTS: The median age at diagnosis was 10.5 years, and the male/female ratio was 11:5. As a predisposing condition, hepatitis B virus (HBV) infections were present in 11 (68.8%) and liver cirrhosis in 8 (50.0%). Including 1 patient with a liver transplant, 4 patients (25.0%) underwent a primary operation with complete tumor resection, and 11 (68.8%) received neoadjuvant chemotherapy because of their inoperable state at diagnosis. After neoadjuvant chemotherapy, complete tumor resection was performed in four (36.4%). Thus complete resection was undertaken in a total of eight patients (50.0%). The estimated 5-year survival rate of all patients was 27.3%. The 5-year survival rate for patients who underwent complete tumor resection was 62.5%, and for those who underwent palliative resection or no operation it was 0%. The statistically significant prognostic factors were tumor stage, presence of metastasis, and complete tumor resection. CONCLUSIONS: This study confirmed that complete tumor resection is essential for cure in pediatric patients with HCC, and neoadjuvant chemotherapy improves the tumors' resectability.en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subjectAdolescenten
dc.subjectCarcinoma, Hepatocellular/drugen
dc.subjecttherapy/mortality/pathology/radiography/*surgeryen
dc.subjectChemotherapy, Adjuvanten
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectInfanten
dc.subjectLiver Neoplasms/drug therapy/mortality/pathology/radiography/*surgeryen
dc.subjectMaleen
dc.subjectNeoadjuvant Therapyen
dc.subjectNeoplasm Stagingen
dc.subjectPrognosisen
dc.subjectRetrospective Studiesen
dc.titleClinical characteristics and prognosis of pediatric hepatocellular carcinomaen
dc.typeArticleen
dc.contributor.AlternativeAuthor유승범-
dc.contributor.AlternativeAuthor김현영-
dc.contributor.AlternativeAuthor어홍-
dc.contributor.AlternativeAuthor원재경-
dc.contributor.AlternativeAuthor정성은-
dc.contributor.AlternativeAuthor박귀원-
dc.contributor.AlternativeAuthor김우기-
dc.identifier.doi10.1007/s00268-005-7965-z-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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