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Plasminogen Activator Inhibitor-1의 해마 시냅스 기능 및 Aβ oligomers에 의한 신경세포 손상에 대한 보호 효과에 관한 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 김혜선 | - |
dc.contributor.author | 조하림 | - |
dc.date.accessioned | 2019-06-25T16:14:47Z | - |
dc.date.available | 2019-06-25T16:14:47Z | - |
dc.date.issued | 2012-02 | - |
dc.identifier.other | 000000000592 | - |
dc.identifier.uri | https://hdl.handle.net/10371/155314 | - |
dc.identifier.uri | http://dcollection.snu.ac.kr/jsp/common/DcLoOrgPer.jsp?sItemId=000000000592 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 의과학과, 2012. 2. 김혜선. | - |
dc.description.abstract | Neuroprotection is considered to be necessary for preventing neurodegeneration. Recently, it has been suggested that glia suppress the upregulation of proinflammatory cytokines and attenuate neurodegeneration. Plasminogen activator inhibitor-1 (PAI-1) is a soluble factor that is released from astrocytes. PAI-1 was previously reported to mediate the neuroprotective activity of TGF-beta 1 against N-methyl-D-aspartate receptor-mediated excitotoxicity. However, it is unclear whether PAI-1 influences synaptogenesis and synaptic plasticity; it is also unclear whether PAI-1 exerts neuroprotective effects against neuronal death induced by Aβ1-42 oligomers. First, using immunocytochemical technique, we examined the expression profile of synaptophysin and PSD-95, markers for functional synapses. The expression of polysialic acid-neural cell adhesion molecule (PSA-NCAM) was also examined with immunocytochemistry to explore the effect of PAI-1 on synaptic plasticity. We found that PAI-1 treatment increased protein levels of synaptophysin, PSD-95, and PSA-NCAM in primary cultured hippocampal neurons. In addition, we found that PAI-1 protected primary hippocampal neurons from neurotoxicity induced by Aβ1-42 oligomers. Taken together, our results demonstrate that PAI-1 promoted synaptogenesis and exerts neuroprotective effects against Aβ1-42 oligomers-induced neurotoxicity in rat primary hippocampal neurons and slices. | - |
dc.format.extent | 35 | - |
dc.language.iso | eng | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject.ddc | 610.72 | - |
dc.title | Plasminogen Activator Inhibitor-1의 해마 시냅스 기능 및 Aβ oligomers에 의한 신경세포 손상에 대한 보호 효과에 관한 연구 | - |
dc.type | Thesis | - |
dc.type | Dissertation | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 의과학과 | - |
dc.date.awarded | 2012-02 | - |
dc.identifier.holdings | 000000000006▲000000000011▲000000000592▲ | - |
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