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Clinical efficacy of the gonadotropin-releasing hormone antagonist, ganirelix, in Korean women undergoing controlled ovarian hyperstimulation for in vitro fertilization and embryo transfer with recombinant follicle-stimulating hormone
DC Field | Value | Language |
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dc.contributor.author | Moon, Shin Yong | - |
dc.contributor.author | Ku, Seung-Yup | - |
dc.contributor.author | Kim, Sun Mie | - |
dc.contributor.author | Jee, Byung Chul | - |
dc.contributor.author | Suh, Chang Suk | - |
dc.contributor.author | Choi, Young Min | - |
dc.contributor.author | Kim, Jung Gu | - |
dc.contributor.author | Kim, Seok Hyun | - |
dc.date.accessioned | 2009-11-26 | - |
dc.date.available | 2009-11-26 | - |
dc.date.issued | 2005-05-27 | - |
dc.identifier.citation | J Obstet Gynaecol Res. 2005 Jun;31(3):227-35. | en |
dc.identifier.issn | 1341-8076 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15916659 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15556 | - |
dc.description.abstract | AIM: To assess the clinical efficacy and safety of the gonadotropin-releasing hormone (GnRH) antagonist, ganirelix (Orgalutran), treatment in women undergoing controlled ovarian hyperstimulation (COH) for in vitro fertilization and embryo transfer (IVF-ET) in Korean women. METHODS: This was a non-comparative, open-label, single-center trial carried out on 31 infertile Korean women. A daily dose of 0.25 mg of the GnRH antagonist, ganirelix, was given, beginning on the sixth day of recombinant follicle-stimulating hormone (FSH) treatment. If the ovarian response was low, ganirelix treatment was delayed until the leading follicle reached a mean diameter of 14 mm. The ganirelix treatment was continued until the day of human chorionic gonadotropin (hCG) injection. Descriptive statistics were recorded for all parameters. RESULTS: The median duration of ganirelix treatment was 4 days (range: 2-6 days) and the median total recombinant FSH dose was 1350 IU (900-2350 IU). During ganirelix treatment, the incidence of luteinizing hormone (LH) rises (LH = 10 IU/L) was 3.2% (one of 31 cases). On the day ovulation was triggered by hCG, the mean number of follicles >/=11 mm in diameter was 12.4 +/- 4.5, and the median of serum estradiol concentration was 4289.9 (1893.7-8268.5) pmol/L. The mean number of oocytes per retrieval was 10.9 +/- 6.1. The fertilization rate was 61.5%, and the mean number of replaced embryos was 2.8 +/- 0.6. The mean implantation rate was 10.0%, and the clinical pregnancy rate per transfer was 23.3% (seven of 30 cases) and the ongoing pregnancy rate per transfer was 20.0% (six of 30 cases). CONCLUSION: The results of the present study support ganirelix as a safe, short, convenient and effective treatment for patients undergoing COH for IVF in Korean women. | en |
dc.language.iso | en | - |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Adult | en |
dc.subject | Female | en |
dc.subject | Follicle Stimulating Hormone, Human/administration & dosage | en |
dc.subject | Gonadotropin-Releasing Hormone/*administration & dosage/*analogs & | en |
dc.subject | derivatives/*antagonists & inhibitors | en |
dc.subject | Hormone Antagonists/*administration & dosage | en |
dc.subject | Humans | en |
dc.subject | Infant, Newborn | en |
dc.subject | Male | en |
dc.subject | Pregnancy | en |
dc.subject | Pregnancy Rate | en |
dc.subject | Treatment Outcome | en |
dc.subject | Embryo Transfer | - |
dc.subject | Fertilization in Vitro | - |
dc.subject | Ovulation Induction | - |
dc.title | Clinical efficacy of the gonadotropin-releasing hormone antagonist, ganirelix, in Korean women undergoing controlled ovarian hyperstimulation for in vitro fertilization and embryo transfer with recombinant follicle-stimulating hormone | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 문신용 | - |
dc.contributor.AlternativeAuthor | 구승엽 | - |
dc.contributor.AlternativeAuthor | 김선미 | - |
dc.contributor.AlternativeAuthor | 지병철 | - |
dc.contributor.AlternativeAuthor | 서창석 | - |
dc.contributor.AlternativeAuthor | 최영민 | - |
dc.contributor.AlternativeAuthor | 김정구 | - |
dc.contributor.AlternativeAuthor | 김석현 | - |
dc.identifier.doi | 10.1111/j.1447-0756.2005.00277.x | - |
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