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Significance of PML and p53 protein as molecular prognostic markers of gallbladder carcinomas

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Authors
Chang, Hee Jin; Yoo, Byong Chul; Kim, Sun Whe; Lee, Byung Lan; Kim, Woo Ho
Issue Date
2007-12-26
Publisher
Elsevier
Citation
Pathol Oncol Res. 2007;13(4):326-35. Epub 2007 Dec 25.
Keywords
Carcinoma/*mortality/pathologyFemaleGallbladder Neoplasms/*mortality/pathologyHumansMaleMiddle AgedNeoplasm Proteins/*analysisNuclear Proteins/*analysisPrognosisSurvival RateTranscription Factors/*analysisTumor Markers, Biological/*analysisTumor Suppressor Protein p53/*analysisTumor Suppressor Proteins/*analysis
Abstract
Molecular markers for cancers are not only useful for cancer detection and prognostic prediction, but may also serve as potential therapeutic targets. In order to identify reliable molecular markers for prognostic prediction in gallbladder carcinoma (GBC), we evaluated the immunohistochemical expression of 15 proteins, namely p53, p27, p16, RB, Smad4, PTEN, FHIT, GSTP1, MGMT, E-cadherin, nm23, CD44, TIMP3, S100A4, and promyelocytic leukemia (PML) in 138 cases of GBC using the tissue microarray method. The prognostic significance was analyzed for each protein. Overexpression of p53 and S100A4, and loss of p27, p16, RB, Smad4, FHIT, E-cadherin and PML expression were associated with poor survival. In particular, PML and p53 showed considerable potential as independent prognostic markers. Patients with normal PML and p53 expression displayed favorable outcomes, compared to those showing abnormal expression of either or both proteins (49% vs. 23% in a 5-year survival rate; 60 months vs. 11 months in median survival, respectively; P=0.009). Thus, PML and p53 are potential candidates for development as clinically applicable molecular prognostic markers of GBC, and may be effective therapeutic targets for the disease in the future.
ISSN
1219-4956 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18158568

https://hdl.handle.net/10371/15570
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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