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Nontuberculous mycobacterial pulmonary disease diagnosed by two methods: a prospective cohort study
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyung-Jun | - |
dc.contributor.author | Lee, Jong Hyuk | - |
dc.contributor.author | Yoon, Soon Ho | - |
dc.contributor.author | Kim, Sung A | - |
dc.contributor.author | Kim, Myoung Sil | - |
dc.contributor.author | Choi, Sun Mi | - |
dc.contributor.author | Lee, Jinwoo | - |
dc.contributor.author | Lee, Chang-Hoon | - |
dc.contributor.author | Han, Sung Koo | - |
dc.contributor.author | Yim, Jae-Joon | - |
dc.date.accessioned | 2019-06-26T04:45:26Z | - |
dc.date.available | 2019-06-26T13:46:27Z | - |
dc.date.issued | 2019-05-24 | - |
dc.identifier.citation | BMC Infectious Diseases. 19(1):468 | ko_KR |
dc.identifier.issn | 1471-2334 | - |
dc.identifier.uri | https://hdl.handle.net/10371/156020 | - |
dc.description.abstract | Background
Microbiological criteria for diagnosing nontuberculous mycobacterial pulmonary disease (NTM-PD) include positive culture results from at least two separately expectorated sputum specimens or one bronchial washing or lavage. However, the clinical similarities and differences between patients diagnosed by these two methods remain unclear. We compared clinical features and prognoses of patients with NTM-PD diagnosed from both specimen types. Methods We analysed data from patients who participated in the Seoul National University Hospital NTM-PD cohort (ClinicalTrials.gov identifier: NCT01616745). Baseline demographics, symptoms, radiographic findings, disease progression, and treatment responses were summarized and compared between patients diagnosed from sputum specimens and patients diagnosed from bronchoscopic specimens. Results Three hundred forty-seven patients were included in the analyses. Of these, 279 (80.4%) were diagnosed from two separately expectorated sputum specimens, and 68 (19.6%) were diagnosed from bronchoscopic specimens. Patients diagnosed from sputum specimens had more frequent and severe cough, sputum, postnasal drip, and high St. Georges Respiratory Questionnaire scores. However, the extent and severity of the radiographic lesions, disease progression, and treatment responses were similar for both groups. Further analysis based on the following three groups (sputum culture positive, sputum culture negative/bronchoscopy, and scanty sputum/bronchoscopy groups) suggested that the scanty sputum/bronchoscopy group appeared to have the worst prognosis in terms of both time to progression and time to culture conversion. Conclusions Although some symptoms and quality of life were worse in patients with NTM-PD diagnosed from sputum specimens, their prognoses were similar to those of patients diagnosed by bronchoscopic specimen. We recommend bronchoscopic sampling for patients in whom NTM-PD is suspected clinically or radiographically, especially those who have no or scanty sputum. | ko_KR |
dc.description.sponsorship | This work was supported by grant from the Seoul National University College of Medicine Research Fund, year 2017 (800–20170102). The funder did not have any role in the study | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Clinical medicine | ko_KR |
dc.subject | Cohort studies | ko_KR |
dc.subject | Diagnosis | ko_KR |
dc.subject | Nontuberculous mycobacteria | ko_KR |
dc.subject | Progression | ko_KR |
dc.title | Nontuberculous mycobacterial pulmonary disease diagnosed by two methods: a prospective cohort study | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김형준 | - |
dc.contributor.AlternativeAuthor | 이종혁 | - |
dc.contributor.AlternativeAuthor | 윤순호 | - |
dc.contributor.AlternativeAuthor | 김성아 | - |
dc.contributor.AlternativeAuthor | 김명실 | - |
dc.contributor.AlternativeAuthor | 최선미 | - |
dc.contributor.AlternativeAuthor | 이진우 | - |
dc.contributor.AlternativeAuthor | 이창훈 | - |
dc.contributor.AlternativeAuthor | 한성구 | - |
dc.contributor.AlternativeAuthor | 임재 | - |
dc.identifier.doi | 10.1186/s12879-019-4078-0 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2019-05-26T05:05:23Z | - |
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