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The C19007T polymorphism of ERCC1 and its correlation with the risk of epithelial ovarian and endometrial cancer in Korean women. A case control study

Cited 14 time in Web of Science Cited 15 time in Scopus
Authors
Jo, Hoenil; Kang, Sokbom; Kim, Sung Il; Kim, Jae Weon; Park, Noh Hyun; Song, Yong Sang; Park, Sang-Yoon; Kang, Soon Beom; Lee, Hyo Pyo
Issue Date
2007-02-23
Publisher
Karger
Citation
Gynecol Obstet Invest. 2007;64(2):84-8. Epub 2007 Feb 20.
Keywords
AdolescentAdultAgedCase-Control StudiesChi-Square DistributionDNA-Binding Proteins/*geneticsEndometrial Neoplasms/epidemiology/*genetics/pathologyEndonucleases/*geneticsFemaleGenotypeHumansKorea/epidemiologyLogistic ModelsMiddle AgedNeoplasms, Glandular and Epithelial/epidemiology/*genetics/pathologyOdds RatioOvarian Neoplasms/epidemiology/*genetics/pathology*Polymorphism, GeneticProspective StudiesRisk Factors
Abstract
BACKGROUND: Excision repair cross-complementing group 1 (ERCC1) is a major DNA repair protein. Recent studies have addressed the association between ERCC1 polymorphism and carcinogenesis. METHODS: We investigated a polymorphism of ERCC1 at nucleotide 19007 (C-->T, Asn118Asn) in 94 epithelial ovarian cancer patients, 102 endometrial cancer patients, and in 329 control subjects. RESULTS: We observed no evidence of associations between the C19007T ERCC1 polymorphism and risk of epithelial ovarian or endometrial cancer, which had the same adjusted odds ratios of 0.91 (p = 0.711, 0.691 respectively). CONCLUSION: Our findings suggest that the C19007T ERCC1 polymorphism is unlikely to play an important role in epithelial ovarian or endometrial cancer in Korean women.
ISSN
1423-002X (Electronic)
Language
English
URI
http://content.karger.com/produktedb/produkte.asp?typ=pdf&file=000100008

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17314486

https://hdl.handle.net/10371/15613
DOI
https://doi.org/10.1159/000100008
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College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
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