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The C19007T polymorphism of ERCC1 and its correlation with the risk of epithelial ovarian and endometrial cancer in Korean women. A case control study
Cited 15 time in
Web of Science
Cited 16 time in Scopus
- Authors
- Issue Date
- 2007-02-23
- Publisher
- Karger
- Citation
- Gynecol Obstet Invest. 2007;64(2):84-8. Epub 2007 Feb 20.
- Keywords
- Adolescent ; Adult ; Aged ; Case-Control Studies ; Chi-Square Distribution ; DNA-Binding Proteins/*genetics ; Endometrial Neoplasms/epidemiology/*genetics/pathology ; Endonucleases/*genetics ; Female ; Genotype ; Humans ; Korea/epidemiology ; Logistic Models ; Middle Aged ; Neoplasms, Glandular and Epithelial/epidemiology/*genetics/pathology ; Odds Ratio ; Ovarian Neoplasms/epidemiology/*genetics/pathology ; Prospective Studies ; Risk Factors ; Polymorphism, Genetic
- Abstract
- BACKGROUND: Excision repair cross-complementing group 1 (ERCC1) is a major DNA repair protein. Recent studies have addressed the association between ERCC1 polymorphism and carcinogenesis. METHODS: We investigated a polymorphism of ERCC1 at nucleotide 19007 (C-->T, Asn118Asn) in 94 epithelial ovarian cancer patients, 102 endometrial cancer patients, and in 329 control subjects. RESULTS: We observed no evidence of associations between the C19007T ERCC1 polymorphism and risk of epithelial ovarian or endometrial cancer, which had the same adjusted odds ratios of 0.91 (p = 0.711, 0.691 respectively). CONCLUSION: Our findings suggest that the C19007T ERCC1 polymorphism is unlikely to play an important role in epithelial ovarian or endometrial cancer in Korean women.
- ISSN
- 1423-002X (Electronic)
- Language
- English
- URI
- http://content.karger.com/produktedb/produkte.asp?typ=pdf&file=000100008
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17314486
https://hdl.handle.net/10371/15613
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