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Lithium down-regulates the expression of CXCR4 in human neutrophils

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dc.contributor.authorKim, Hyun Kyung-
dc.contributor.authorKim, Ji-Eun-
dc.contributor.authorChung, Junho-
dc.contributor.authorPark, Ki Ho-
dc.contributor.authorHan, Kyou-Sup-
dc.contributor.authorCho, Han-Ik-
dc.date.accessioned2009-11-26T02:14:33Z-
dc.date.available2009-11-26T02:14:33Z-
dc.date.issued2007-08-19-
dc.identifier.citationJ Trace Elem Med Biol. 2007;21(3):204-9. Epub 2007 May 9.en
dc.identifier.issn0946-672X (Print)-
dc.identifier.urihttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7GJC-4NP3P2H-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=22cb23651740966e068b4424cfb69eb9-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17697959-
dc.identifier.urihttps://hdl.handle.net/10371/15621-
dc.description.abstractThe CXC chemokine receptor CXCR4 and its unique ligand SDF-1 (stromal-derived factor-1) play critical roles for the retention of hematopoietic cells within the bone marrow (BM) and for their mobilization into the circulation. Lithium often produces neutrophilia in psychiatric patients, but the mechanism of mobilization related to neutrophilia has not been fully clarified. We showed here that lithium dose-dependently reduces the levels of surface CXCR4 protein and mRNA in neutrophils, but not in lymphocytes. The chemotactic migration of neutrophils in response to SDF-1 was reduced after a pre-incubation with lithium. We provide evidence that lithium down-regulates the CXCR4 expression of neutrophils and it attenuates their responsiveness to SDF-1. Our studies support the concept that down-regulation of CXCR4 is one of the mechanisms by which causes neutrophilia.en
dc.language.isoenen
dc.publisherUrban & Fischeren
dc.subjectApoptosis/drug effectsen
dc.subjectChemokine CXCL12en
dc.subjectChemokines, CXC/pharmacologyen
dc.subjectChemotaxis, Leukocyte/drug effectsen
dc.subjectDown-Regulationen
dc.subjectHumansen
dc.subjectLeukocytes, Mononuclear/*drug effects/*metabolismen
dc.subjectLithium Compounds/*pharmacologyen
dc.subjectNeutrophils/drug effects/metabolismen
dc.subjectRNA, Messenger/metabolismen
dc.subjectReceptors, CXCR4/*biosynthesisen
dc.titleLithium down-regulates the expression of CXCR4 in human neutrophilsen
dc.typeArticleen
dc.contributor.AlternativeAuthor김현경-
dc.contributor.AlternativeAuthor김지은-
dc.contributor.AlternativeAuthor정준호-
dc.contributor.AlternativeAuthor박기호-
dc.contributor.AlternativeAuthor한규섭-
dc.contributor.AlternativeAuthor조한익-
dc.identifier.doi10.1016/j.jtemb.2007.03.001-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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