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Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy

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dc.contributor.authorGotsch, Francesca-
dc.contributor.authorRomero, Roberto-
dc.contributor.authorEspinoza, Jimmy-
dc.contributor.authorKusanovic, Juan Pedro-
dc.contributor.authorMazaki-Tovi, Shali-
dc.contributor.authorErez, Offer-
dc.contributor.authorThan, Nandor Gabor-
dc.contributor.authorEdwin, Samuel-
dc.contributor.authorMazor, Moshe-
dc.contributor.authorYoon, Bo Hyan-
dc.contributor.authorHassan, Sonia S-
dc.date.accessioned2009-11-26T02:26:41Z-
dc.date.available2009-11-26T02:26:41Z-
dc.date.issued2007-09-01-
dc.identifier.citationJ Matern Fetal Neonatal Med. 2007 Oct;20(10):735-44.en
dc.identifier.issn1476-7058 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17763275-
dc.identifier.urihttp://hdl.handle.net/10371/15632-
dc.description.abstractOBJECTIVE: Acute pyelonephritis is one of the most frequent medical complications of pregnancy, as well as a common cause of antepartum hospitalization. Interferon (IFN)-gamma inducible protein, CXCL10/IP-10, is a member of the CXC chemokine family with pro-inflammatory and anti-angiogenic properties. The purpose of this study was to determine whether maternal serum concentrations of CXCL10/IP-10 change in patients with acute pyelonephritis during pregnancy. STUDY DESIGN: This cross-sectional study was conducted to determine the difference in maternal serum concentrations of CXCL10/IP-10 in pregnant women with acute pyelonephritis (N = 41) and normal pregnant women (N = 89). Pyelonephritis was defined in the presence of a positive urine culture, fever, and maternal clinical signs; blood cultures were performed in 36 cases. Maternal serum concentrations of CXCL10/IP-10 were measured by a sensitive immunoassay. Non-parametric statistics were used for analysis. RESULTS: (1) The median serum concentration of CXCL10/IP-10 in pregnant patients with pyelonephritis was significantly higher than in normal pregnant women (median 318.5 pg/mL, range 78.8-2459.2 vs. median 116.1 pg/mL, range 40.7-1314.3, respectively; p < 0.001); (2) maternal median serum concentrations of CXCL10/IP-10 did not differ significantly among patients with acute pyelonephritis with and without bacteremia (positive blood cultures: median 362.6 pg/mL, range 100.2-2459.2 vs. negative blood cultures: median 298.9 pg/mL, range 108.5-1148.7, respectively; p = 0.3). CONCLUSIONS: Pyelonephritis in pregnant women is associated with an increased maternal serum concentration of the chemokine CXCL10/IP-10.en
dc.language.isoen-
dc.publisherTaylor & Francisen
dc.subjectBacteremia/blooden
dc.subjectBacteriuria/complicationsen
dc.subjectBiological Markersen
dc.subjectCase-Control Studiesen
dc.subjectChemokine CXCL10/*blooden
dc.subjectCross-Sectional Studiesen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectPregnancyen
dc.subjectPregnancy Complications, Infectious/*blood/immunologyen
dc.subjectPyelonephritis/*blood/complications/immunologyen
dc.titleMaternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancyen
dc.typeArticleen
dc.identifier.doi10.1080/14767050701511650-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
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