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Proliferation of activated CD1d-restricted NKT cells is down-modulated by lymphocyte activation gene-3 signaling via cell cycle arrest in S phase
Cited 29 time in
Web of Science
Cited 29 time in Scopus
- Authors
- Issue Date
- 2006-12-19
- Publisher
- Elsevier
- Citation
- Cell Biol Int. 2007 Mar;31(3):257-62. Epub 2006 Nov 14.
- Keywords
- Animals ; Antigens, CD/*immunology ; Antigens, CD1/*immunology ; Cell Proliferation ; Down-Regulation ; Gene Expression Regulation/*immunology ; Immunologic Factors ; Killer Cells, Natural/*cytology/*immunology ; Lymphocyte Activation/*genetics ; Mice ; S Phase/genetics ; Signal Transduction/*immunology ; Transduction, Genetic
- Abstract
- Upon antigenic stimulation, CD1d-restricted NKT cells quickly secrete large amounts of cytokines. This prompt response demonstrates that CD1d-restricted NKT cells may potentially prove to be useful therapeutic agents for the treatment of many diseases. Despite the clinical importance of CD1d-restricted NKT cells, the regulating mechanisms of this unique T cell population remain to be defined. We found murine LAG-3 is inducible on CD1d-restricted NKT cells as the result of a variety of stimulants such as concanavalin A (con A) and anti-CD3. Also, antigen-specific CD1d stimulation can elicit LAG-3 in CD1d-restricted NKT cells. Moreover, ectopic LAG-3 expression on CD1d-restricted NKT cells results in cell cycle arrest in the S phase. These results show that LAG-3 signaling on activated CD1d-restricted NKT cells may down-modulate NKT cell proliferation.
- ISSN
- 1065-6995 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17175182
https://hdl.handle.net/10371/15696
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