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Radiofrequency ablation of hepatocellular carcinoma in patients with decompensated cirrhosis: evaluation of therapeutic efficacy and safety
DC Field | Value | Language |
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dc.contributor.author | Kim, Young Kon | - |
dc.contributor.author | Kim, Chong Soo | - |
dc.contributor.author | Chung, Gyong Ho | - |
dc.contributor.author | Han, Young Min | - |
dc.contributor.author | Lee, Sang Yong | - |
dc.contributor.author | Jin, Gong Yong | - |
dc.contributor.author | Lee, Jeong Min | - |
dc.date.accessioned | 2009-11-26T02:57:47Z | - |
dc.date.available | 2009-11-26T02:57:47Z | - |
dc.date.issued | 2006-04-25 | - |
dc.identifier.citation | AJR Am J Roentgenol. 2006 ;186(5 Suppl):S261-268. | en |
dc.identifier.issn | 0361-803X (Print) | - |
dc.identifier.issn | 1546-3141 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16632686 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15701 | - |
dc.description.abstract | OBJECTIVE: Our objective was to determine the therapeutic efficacy and safety of radiofrequency ablation in the treatment of hepatocellular carcinoma (HCC) in patients with decompensated cirrhosis. SUBJECTS AND METHODS: Nineteen patients with 26 HCC nodules (range, 0.8-5 cm; mean, 1.96 cm) and decompensated liver cirrhosis (mean Child score, 10.7) were treated with radiofrequency ablation using cooled-tip electrodes and a 200-W generator. Radiofrequency ablation was performed under the guidance of sonography or CT. Procedure-related complications, therapeutic efficacy, each patient's survival, changes in blood test results--that is, serum aminotransferase and bilirubin--and changes in the Child score before and after ablation therapy were analyzed. To assess the therapeutic response of the tumor to radiofrequency ablation, we performed contrast-enhanced CT after the procedure and during follow-up. RESULTS: Complete necrosis without marginal recurrence at the 6-month follow-up was attained in 23 lesions (88.5%). During follow-up (mean, 13.3 months), one patient experienced a remote tumor recurrence in the liver. The median survival time was 12.0 +/- 1.7 months. Two patients died of liver failure--one at 2 months and one at 4 months after treatment. The other patients were followed for at least 6 months (range, 6-28 months; mean, 12 months). The first and second weeks after therapy, the serum aminotransferase and bilirubin levels were significantly higher than were pretreatment levels (p < 0.05). However, 3 weeks after therapy, those figures were nearly restored to the pretreatment levels. The mean Child scores 3 weeks after radiofrequency ablation (10.8) were similar to those before treatment (10.7). CONCLUSION: Radiofrequency ablation can be used selectively for treatment of HCC in patients with decompensated cirrhosis but has the potential to aggravate the preexisting hepatic dysfunction. | en |
dc.language.iso | en | - |
dc.publisher | American Roentgen Ray Society | en |
dc.subject | cirrhosis | en |
dc.subject | decompensation | en |
dc.subject | hepatocellular carcinoma | en |
dc.subject | live | en |
dc.subject | radiofrequency ablation | en |
dc.subject | Carcinoma, Hepatocellular/*complications/*surgery | en |
dc.subject | Liver Neoplasms/*complications/*surgery | en |
dc.subject | Catheter Ablation/adverse effects | - |
dc.title | Radiofrequency ablation of hepatocellular carcinoma in patients with decompensated cirrhosis: evaluation of therapeutic efficacy and safety | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김영곤 | - |
dc.contributor.AlternativeAuthor | 김종수 | - |
dc.contributor.AlternativeAuthor | 정경호 | - |
dc.contributor.AlternativeAuthor | 한영민 | - |
dc.contributor.AlternativeAuthor | 이상용 | - |
dc.contributor.AlternativeAuthor | 진공용 | - |
dc.contributor.AlternativeAuthor | 이정민 | - |
dc.identifier.doi | 10.2214/AJR.04.1266 | - |
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