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Effect of mechanical strain on human limbal epithelial cells in vitro
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- Authors
- Issue Date
- 2006-12-16
- Publisher
- Taylor & Francis
- Citation
- Curr Eye Res. 2006 Dec;31(12):1015-20.
- Keywords
- Blotting, Western ; Cell Adhesion Molecules/*biosynthesis ; Cell Shape ; Cells, Cultured ; Enzyme-Linked Immunosorbent Assay ; Epithelial Cells/*physiology ; Extracellular Matrix/*metabolism ; Fibronectins/*biosynthesis ; Humans ; Limbus Corneae/*cytology ; Stress, Mechanical
- Abstract
- PURPOSE: To investigate the effects of the mechanical cyclic strain on the extracellular matrix (ECM) production by cultivated human limbal epithelial cells (HLECs) in vitro. METHODS: HLECs were repetitively stretched and relaxed by 20% of their original length. Morphology of HLECs was observed, and concentrations of fibronectin and laminin V were measured. RESULTS: The strained HLECs were elongated and aligned perpendicular to the direction of force. Fibronectin and laminin V were highly expressed in the strain group compared with the control. CONCLUSIONS: Cyclic strain induces the synthesis of fibronectin and laminin V in cultivated HLECs.
- ISSN
- 0271-3683 (Print)
- Language
- English
- URI
- http://www.informaworld.com/smpp/content~db=all?content=10.1080/02713680601038832
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17169839
https://hdl.handle.net/10371/15704
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