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Effect of glycine on recovery of bladder smooth muscle contractility after acute urinary retention in rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Sung K | - |
dc.contributor.author | Son, Hwancheol | - |
dc.contributor.author | Kim, Soo W | - |
dc.contributor.author | Oh, Seung-June | - |
dc.contributor.author | Choi, Hwang | - |
dc.date.accessioned | 2009-11-26T03:02:54Z | - |
dc.date.available | 2009-11-26T03:02:54Z | - |
dc.date.issued | 2005-11-17 | - |
dc.identifier.citation | BJU Int. 2005 Dec;96(9):1403-8. | en |
dc.identifier.issn | 1464-4096 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16287466 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15719 | - |
dc.description.abstract | OBJECTIVE: To investigate the effects of glycine on the recovery of bladder smooth muscle contractility after acute urinary retention. MATERIALS AND METHODS: Bladder overdistension was induced in Sprague-Dawley rats by an infusion of saline (twice the threshold volume), maintained for 2 h. From 15 min before emptying of the bladder until 2 h after, saline or glycine solution was infused i.v. At 30 min, 2 h and 1 week after bladder emptying, samples of bladder tissue were taken for muscle strip study, malondialdehyde (MDA) assay, ATP assay, Western blotting for apoptosis-related molecules (Bcl-2, Bax, Caspase-3), and histological analysis including terminal deoxynucleotidyl transferase-mediated nick-end labelling staining. The results were compared among normal control, saline-treated and glycine-treated rats. RESULTS: In the glycine-treated group, muscle strip contractile responses induced by electrical-field stimulation and carbachol were both significantly greater at 1 week after bladder emptying than in the saline-treated group. The results of the ATP assay appeared to correspond with those of the muscle strip study. The saline-treated group had significantly higher MDA levels at 30 min after bladder emptying than the glycine-treated group. At 2 h after bladder emptying, there was significantly more apoptosis and greater leukocyte infiltration in the saline-treated group than in the glycine-treated group. While pro-apoptotic Bax and caspase-3 were down-regulated, Bcl-2 was up-regulated in the glycine-treated group. CONCLUSION: Glycine infusions might improve the contractile responses of bladder smooth muscle after acute urinary retention by reducing oxidative damage and apoptosis. | en |
dc.language.iso | en | en |
dc.publisher | Blackwell Publishing | en |
dc.subject | Animals | en |
dc.subject | Apoptosis/drug effects | en |
dc.subject | Blotting, Western | en |
dc.subject | Female | en |
dc.subject | Glycine/*pharmacology | en |
dc.subject | Glycine Agents/*pharmacology | en |
dc.subject | Muscle Contraction/*drug effects | en |
dc.subject | Muscle, Smooth/*drug effects | en |
dc.subject | Proto-Oncogene Proteins c-bcl-2/metabolism | en |
dc.subject | Rats | en |
dc.subject | Rats, Sprague-Dawley | en |
dc.subject | Urinary Bladder/*drug effects | en |
dc.subject | Urinary Retention/*physiopathology | en |
dc.title | Effect of glycine on recovery of bladder smooth muscle contractility after acute urinary retention in rats | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 손환철 | - |
dc.contributor.AlternativeAuthor | 오성준 | - |
dc.contributor.AlternativeAuthor | 최황 | - |
dc.identifier.doi | 10.1111/j.1464-410X.2005.05855.x | - |
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