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Granulocyte colony-stimulating factor enhances angiogenesis after focal cerebral ischemia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Soon-Tae | - |
dc.contributor.author | Chu, Kon | - |
dc.contributor.author | Jung, Keun-Hwa | - |
dc.contributor.author | Ko, Song-Yi | - |
dc.contributor.author | Kim, Eun-Hee | - |
dc.contributor.author | Sinn, Dong In | - |
dc.contributor.author | Lee, Yong Seok | - |
dc.contributor.author | Lo, Eng H | - |
dc.contributor.author | Kim, Manho | - |
dc.contributor.author | Roh, Jae Kyu | - |
dc.date.accessioned | 2009-11-26T04:46:35Z | - |
dc.date.available | 2009-11-26T04:46:35Z | - |
dc.date.issued | 2005-09-10 | - |
dc.identifier.citation | Brain Res. 2005 Oct 5;1058(1-2):120-8. Epub 2005 Sep 8. | en |
dc.identifier.issn | 1872-6240 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16150422 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15844 | - |
dc.description.abstract | Granulocyte colony-stimulating factor (G-CSF) is a neuroprotective agent and activates endothelial proliferation and bone marrow stem cell mobilization. We studied the effect of G-CSF on angiogenesis and neurological recovery after focal cerebral ischemia. After the induction of transient focal ischemia in rats, G-CSF (50 micro/day, i.p.) or PBS was administered for 3 days. We evaluated the functional recovery, infarct volume, inflammatory infiltration, blood-brain barrier (BBB) disruption, hemispheric atrophy, protein expressions of endothelial nitric oxide synthase (eNOS) and angiopoietins, and the therapeutic time window of G-CSF administration. We then analyzed endothelial cell proliferation, the vascular surface area, the number of branch points, and the vascular length. G-CSF treatment improved behavioral recovery and reduced the infarct volume, the inflammatory infiltration, the BBB disruption, and the hemispheric atrophy. G-CSF injection, starting at 2 h, 1 day, or 4 days after ischemia, resulted in a better functional recovery and a greater reduction in hemispheric atrophy than injection starting at day 7. The vascular surface area, the vascular branch points, the vascular length, the number of BrdU(+) endothelial cells, and eNOS/angiopoietin-2 expression were significantly increased in the G-CSF group compared with the ischemia-only group. G-CSF injection starting at 1 day induced larger endothelial proliferation compared with injection starting at 7 days. In this study, we provide evidences that G-CSF enhances the angiogenesis and reduces the ischemic damage, which promotes the long-term functional recovery. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Angiopoietin-1/analogs & derivatives/metabolism | en |
dc.subject | Animals | en |
dc.subject | Atrophy/drug therapy/pathology/physiopathology | en |
dc.subject | Blood-Brain Barrier/drug effects/physiology | en |
dc.subject | Brain/blood supply/*drug effects/physiopathology | en |
dc.subject | Brain Infarction/drug therapy/pathology/physiopathology | en |
dc.subject | Brain Ischemia/*drug therapy/pathology/physiopathology | en |
dc.subject | Cell Proliferation/drug effects | en |
dc.subject | Cerebral Arteries/*drug effects/physiology | en |
dc.subject | Drug Administration Schedule | en |
dc.subject | Encephalitis/etiology/pathology/physiopathology | en |
dc.subject | Endothelial Cells/drug effects/physiology | en |
dc.subject | Granulocyte-Macrophage Colony-Stimulating Factor/*pharmacology/therapeuticuse | en |
dc.subject | Male | en |
dc.subject | Neovascularization, Physiologic/*drug effects/physiology | en |
dc.subject | Neuroprotective Agents/pharmacology/therapeutic use | en |
dc.subject | Nitric Oxide Synthase Type III/drug effects/metabolism | en |
dc.subject | Rats | en |
dc.subject | Rats, Sprague-Dawley | en |
dc.subject | Recovery of Function/drug effects/physiology | en |
dc.subject | Treatment Outcome | en |
dc.title | Granulocyte colony-stimulating factor enhances angiogenesis after focal cerebral ischemia | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이순태 | - |
dc.contributor.AlternativeAuthor | 조건 | - |
dc.contributor.AlternativeAuthor | 정근화 | - |
dc.contributor.AlternativeAuthor | 고송이 | - |
dc.contributor.AlternativeAuthor | 김은희 | - |
dc.contributor.AlternativeAuthor | 신동인 | - |
dc.contributor.AlternativeAuthor | 이용석 | - |
dc.contributor.AlternativeAuthor | 김만호 | - |
dc.contributor.AlternativeAuthor | 노재규 | - |
dc.identifier.doi | 10.1016/j.brainres.2005.07.076 | - |
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