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Vascular endothelial growth factor gene +405 C/G polymorphism is associated with susceptibility to advanced stage endometriosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sung Hoon | - |
dc.contributor.author | Choi, Young Min | - |
dc.contributor.author | Choung, Seon Ha | - |
dc.contributor.author | Jun, Jong Kwan | - |
dc.contributor.author | Kim, Jung Gu | - |
dc.contributor.author | Moon, Shin Yong | - |
dc.date.accessioned | 2009-11-26T05:26:35Z | - |
dc.date.available | 2009-11-26T05:26:35Z | - |
dc.date.issued | 2005-06-28 | - |
dc.identifier.citation | Hum Reprod. 2005 Oct;20(10):2904-8. Epub 2005 Jun 24 | en |
dc.identifier.issn | 0268-1161 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15979997 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15942 | - |
dc.description.abstract | BACKGROUND: Vascular endothelial growth factor (VEGF) is known to play a pivotal role in the development of endometriosis. This study was performed to investigate whether the VEGF gene 5'-untranslated region polymorphism is associated with susceptibility to advanced stage endometriosis. METHODS: This study comprised 215 women with advanced stage endometriosis, 219 control women without endometriosis, and 70 fertile women. Following extraction of genomic DNA, genotyping of the -460 C/T and +405 C/G polymorphisms of the VEGF gene were performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. RESULTS: The distribution of genotypes and allele frequencies of the -460 C/T polymorphism in the endometriosis group did not differ from those in the control group and the fertile women group. However, genotype distribution of the +405 C/G polymorphism was significantly different between patients with and without endometriosis (P = 0.01) and between patients with endometriosis and the fertile women (P = 0.02). Patients with endometriosis showed a higher incidence of the +405 CC genotype compared with the controls and the fertile women (P = 0.007 and 0.016 respectively). CONCLUSIONS: These findings suggest that the VEGF +405 C/G polymorphism may be associated with the risk of advanced stage endometriosis in the Korean population. | en |
dc.language.iso | en | - |
dc.publisher | Oxford University Press | en |
dc.subject | Alleles | en |
dc.subject | Case-Control Studies | en |
dc.subject | Endometriosis/*genetics | en |
dc.subject | Female | en |
dc.subject | Gene Frequency | en |
dc.subject | Genetic Predisposition to Disease | en |
dc.subject | Genotype | en |
dc.subject | Haplotypes | en |
dc.subject | Humans | en |
dc.subject | Korea | en |
dc.subject | Odds Ratio | en |
dc.subject | Polymorphism, Restriction Fragment Length | en |
dc.subject | Sequence Analysis, DNA | en |
dc.subject | Vascular Endothelial Growth Factor A/*genetics/metabolism | en |
dc.subject | Polymorphism, Genetic | - |
dc.title | Vascular endothelial growth factor gene +405 C/G polymorphism is associated with susceptibility to advanced stage endometriosis | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김성훈 | - |
dc.contributor.AlternativeAuthor | 최영민 | - |
dc.contributor.AlternativeAuthor | 정선하 | - |
dc.contributor.AlternativeAuthor | 전종관 | - |
dc.contributor.AlternativeAuthor | 김정구 | - |
dc.contributor.AlternativeAuthor | 문신용 | - |
dc.identifier.doi | 10.1093/humrep/dei146 | - |
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