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Immunohistochemical study of the distribution of sodium-dependent vitamin C transporters in adult rat brain

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dc.contributor.authorMun, Ga Hee-
dc.contributor.authorKim, Myeung Ju-
dc.contributor.authorLee, Ju Hyun-
dc.contributor.authorKim, Hyun Jun-
dc.contributor.authorChung, Yoon Hee-
dc.contributor.authorChung, Young Bae-
dc.contributor.authorKang, Jae Seung-
dc.contributor.authorHwang, Young Il-
dc.contributor.authorOh, Seung Ha-
dc.contributor.authorKim, Joong-Gon-
dc.contributor.authorHwang, Douk Ho-
dc.contributor.authorShin, Dong Hoon-
dc.contributor.authorLee, Wang Jae-
dc.date.accessioned2009-11-26T05:31:32Z-
dc.date.available2009-11-26T05:31:32Z-
dc.date.issued2006-02-16-
dc.identifier.citationJ Neurosci Res. 2006 Apr;83(5):919-28.en
dc.identifier.issn0360-4012 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16477646-
dc.identifier.urihttps://hdl.handle.net/10371/15954-
dc.description.abstractSodium-dependent vitamin C transporters (SVCTs) is known to transport the reduced form of ascorbic acid into the cell, whereas the oxidized form of vitamin C (VC) is moved through a facilitative sugar transporter, such as glucose transporter (GLUT). With regard to the distribution of SVCT1 and -2 within the various organs, they were reported to be expressed in different types of cells. Especially in the central nervous system, only SVCT2 mRNA was expressed mainly in neurons and some types of neuroglial cells. However, data on the expression of SVCT proteins in the brain are scant. Therefore, we tried to develop comprehensive data on the distribution of SVCT proteins in adult rat brain by using immunohistochemical techniques for the first time. In our study, SVCT2 immunoreactivities (IRs) were intensely localized in the neurons of cerebral cortex, hippocampus, and Purkinje cells of cerebellum, and much weaker SVCT2 IRs were found in the other brain regions. Judging from double-immunohistochemical data, most of the cells expressing SVCT2 IRs were likely to be neurons or microglia, even though the cells in choroids plexus or ependymal cells around the ventricles also exhibited SVCT2 IRs. Complete mapping of the distribution of SVCT2 IRs was available by using a semiquantitative method. The subcellular localization of SVCT proteins is necessary for understanding the exact role of the protein, so the current overall mapping of SVCT IRs in the rat brain could be the basis for further studies on related subjects.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subjectAnimalsen
dc.subjectBlotting, Westernen
dc.subjectBrain/*metabolismen
dc.subjectImmunohistochemistryen
dc.subjectMicroglia/metabolismen
dc.subjectNeurons/metabolismen
dc.subjectOrganic Anion Transporters, Sodium-Dependent/*metabolismen
dc.subjectRatsen
dc.subjectReverse Transcriptase Polymerase Chain Reactionen
dc.subjectSymporters/*metabolismen
dc.titleImmunohistochemical study of the distribution of sodium-dependent vitamin C transporters in adult rat brainen
dc.typeArticleen
dc.contributor.AlternativeAuthor문가희-
dc.contributor.AlternativeAuthor김명주-
dc.contributor.AlternativeAuthor이주현-
dc.contributor.AlternativeAuthor김현준-
dc.contributor.AlternativeAuthor정윤희-
dc.contributor.AlternativeAuthor정영배-
dc.contributor.AlternativeAuthor강재승-
dc.contributor.AlternativeAuthor황영일-
dc.contributor.AlternativeAuthor오승하-
dc.contributor.AlternativeAuthor김중곤-
dc.contributor.AlternativeAuthor황덕호-
dc.contributor.AlternativeAuthor신동훈-
dc.contributor.AlternativeAuthor이왕재-
dc.identifier.doi10.1002/jnr.20751-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Otorhinolaryngology (이비인후과학전공)Journal Papers (저널논문_이비인후과학전공)
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