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Genetic polymorphism of XRCC3 Thr241Met and breast cancer risk: case-control study in Korean women and meta-analysis of 12 studies
DC Field | Value | Language |
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dc.contributor.author | Lee, Sang-Ah | - |
dc.contributor.author | Lee, Kyoung-Mu | - |
dc.contributor.author | Park, Sue Kyung | - |
dc.contributor.author | Choi, Ji-Yeob | - |
dc.contributor.author | Kim, Bongcheol | - |
dc.contributor.author | Nam, Jinwu | - |
dc.contributor.author | Yoo, Keun-Young | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.contributor.author | Ahn, Sei-Hyun | - |
dc.contributor.author | Kang, Daehee | - |
dc.date.accessioned | 2009-11-26T06:17:24Z | - |
dc.date.available | 2009-11-26T06:17:24Z | - |
dc.date.issued | 2006-10-26 | - |
dc.identifier.citation | Breast Cancer Res Treat. 2007 May;103(1):71-6. Epub 2006 Oct 25 | en |
dc.identifier.issn | 0167-6806 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17063279 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15969 | - |
dc.description.abstract | To evaluate the relationship of genetic polymorphism in XRCC3 Thr(241)Met and the risk of breast cancer, a hospital-based case-control study was conducted in Korea. Histologically confirmed breast cancer cases (n = 574) and controls (n = 502) with no present or previous history of cancer were recruited from several teaching hospitals in Seoul during 1995-2001. Information on demographic characteristics and other information were collected by interviewed questionnaire. Genetic polymorphisms of XRCC3 Thr(241)Met (C > T) was determined by single base extention assay. The frequency of Thr/Thr, Thr/Met, and Met/Met genotype were 89.4, 10.4, 0.2% in cases and 92.3, 7.7, 0.0% in controls, respectively. Genotype distribution in controls fit well to the Hardy-Weinberg equilibrium (P = 0.74). XRCC3 codon 241 Thr/Met or Met/Met genotype moderately increased the risk of breast cancer (OR = 1.4, 95% CI: 0.87-2.33), but not significant in this study. In the results of meta-analysis using twelve reports, however, Thr/Met or Met/Met genotype increased the risk of breast cancer (OR = 1.08, 95%CI: 1.00-1.17). In conclusion, although the genetic polymorphism of XRCC3 Thr(241)Met was unlikely to have a substantial overall association in Korean women, the meta-analysis of studies, including ours, provided that Thr/Met and Met/Met was weakly increased the risk of breast cancer compare to Thr/Thr genotype. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Asian Continental Ancestry Group/*genetics | en |
dc.subject | Breast Neoplasms/epidemiology/*genetics | en |
dc.subject | Case-Control Studies | en |
dc.subject | DNA-Binding Proteins/*genetics | en |
dc.subject | European Continental Ancestry Group/genetics | en |
dc.subject | Female | en |
dc.subject | Genetic Predisposition to Disease/epidemiology/*genetics | en |
dc.subject | Humans | en |
dc.subject | Korea/epidemiology | en |
dc.subject | Middle Aged | en |
dc.subject | Polymorphism, Genetic | - |
dc.title | Genetic polymorphism of XRCC3 Thr241Met and breast cancer risk: case-control study in Korean women and meta-analysis of 12 studies | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이상아 | - |
dc.contributor.AlternativeAuthor | 이경무 | - |
dc.contributor.AlternativeAuthor | 박수경 | - |
dc.contributor.AlternativeAuthor | 최지엽 | - |
dc.contributor.AlternativeAuthor | 김봉철 | - |
dc.contributor.AlternativeAuthor | 유근영 | - |
dc.contributor.AlternativeAuthor | 노동영 | - |
dc.contributor.AlternativeAuthor | 안세현 | - |
dc.contributor.AlternativeAuthor | 강대희 | - |
dc.identifier.doi | 10.1007/s10549-006-9348-z | - |
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