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Surgical outcome of epilepsy caused by cortical dysplasia

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dc.contributor.authorChung, Chun Kee-
dc.contributor.authorLee, Sang Kun-
dc.contributor.authorKim, Ki Joong-
dc.date.accessioned2009-11-26T07:33:36Z-
dc.date.available2009-11-26T07:33:36Z-
dc.date.issued2005-04-09-
dc.identifier.citationEpilepsia. 2005;46 Suppl 1:25-9.en
dc.identifier.issn0013-9580 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15816975-
dc.identifier.urihttp://hdl.handle.net/10371/16126-
dc.description.abstractPURPOSE: Cortical dysplasia (CD) is the second most common pathologic entity in surgically treated epilepsy. To delineate its surgical outcome and prognostic factors, we performed a retrospective analysis of patients operated on at a single institute. METHODS: Between September 1994 and December 2000, 128 cases with CD were operated on at our institute. The male/female ratio was 85:43, and the mean age was 27 years (SD, 7.6 years). The mean postoperative follow-up period was 26.9 months (SD, 12.0 months). Seizure outcome and severity of CD were classified according to Engel's and Mischel's classifications, respectively. Severity of CD was mild in 69, moderate in 21, and severe in 38. Lobar distribution was temporal in 54, frontal in 48, and others in 26. Cortical resection, lobectomy, or hemispherectomy was done in all patients. Univariate analysis was done followed by multivariate analysis by using computerized statistical software. RESULTS: Postoperative seizure outcome was Engel class I in 58 (45.3%), II in 17 (13.3%), III in 16 (12.5%), and IV in 37 (28.9%). Transient postoperative complications occurred in 14 (10.9%) patients without mortality or permanent neurologic impairment. Multivariate analysis revealed severity of CD and frontal lobe resection as independent prognostic factors for worse outcome (p = 0.001 and 0.003, respectively). CONCLUSIONS: Epilepsy surgery for CD achieved 45.3% seizure-free rate with 10.9% transient postoperative complications in our institute. Worse postoperative seizure outcome was observed in cases with mild CD and frontal lobe resection.en
dc.language.isoen-
dc.publisherWiley-Blackwellen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectCerebral Cortex/*abnormalities/pathology/*surgeryen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectElectroencephalographyen
dc.subjectEpilepsy/diagnosis/pathology/*surgeryen
dc.subjectEpilepsy, Frontal Lobe/pathology/surgeryen
dc.subjectEpilepsy, Temporal Lobe/pathology/surgeryen
dc.subjectFemaleen
dc.subjectFollow-Up Studiesen
dc.subjectFrontal Lobe/abnormalities/pathology/surgeryen
dc.subjectHumansen
dc.subjectMagnetic Resonance Imagingen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNeurosurgical Procedures/methodsen
dc.subjectPostoperative Complications/epidemiologyen
dc.subjectPrognosisen
dc.subjectSeverity of Illness Indexen
dc.subjectSurvival Analysisen
dc.subjectTemporal Lobe/abnormalities/pathology/surgeryen
dc.subjectTreatment Outcomeen
dc.titleSurgical outcome of epilepsy caused by cortical dysplasiaen
dc.typeArticleen
dc.contributor.AlternativeAuthor정천기-
dc.contributor.AlternativeAuthor이상근-
dc.contributor.AlternativeAuthor김길중-
dc.identifier.doi10.1111/j.0013-9580.2005.461008.x-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Neurosurgery (신경외과학전공)Journal Papers (저널논문_신경외과학전공)
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