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Plasma level of stromal derived factor-1 (SDF-1) is increased in disseminated intravascular coagulation patients who have poor outcomes: in vitro effect of SDF-1 on coagulopathy

Cited 5 time in Web of Science Cited 4 time in Scopus
Authors
Kim, Hyun Kyung; Kim, Ji-Eun; Chung, Junho; Lee, Dong Soon; Han, Kyou-Sup; Park, Seonyang; Cho, Han-Ik
Issue Date
2007-01-24
Publisher
Elsevier
Citation
Thromb Res. 2007;120(4):559-66. Epub 2007 Jan 18.
Keywords
Cells, CulturedChemokine CXCL12Chemokines, CXC/*blood/pharmacologyDisseminated Intravascular Coagulation/*bloodEndothelial Cells/metabolismHumansMonocytes/metabolismPlatelet Function TestsPrognosisThrombomodulin/drug effectsThrombophilia/*etiologyThromboplastin/drug effects
Abstract
Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine that activates and directs the migration of leukocytes that have CXCR4, which is the unique receptor for SDF-1. Although SDF-1/CXCR4 interaction has been implicated in various inflammatory conditions, its role in modulating coagulation has not been determined. We studied the plasma SDF-1 levels in 90 patients with suspected disseminated intravascular coagulation (DIC) and we found that circulating SDF-1 was significantly increased in the overt DIC patients and was also increased in overt DIC patients who have a poor outcome. We then tested in vitro whether SDF-1 can affect the expression of monocyte tissue factor (TF) and endothelial thrombomodulin (TM), and both of these play important roles in coagulopathy. SDF-1 did not affect the expression of surface TF protein and its function and the TF mRNA level in both monocytes and the monocytic leukemia cell line THP-1. SDF-1 also did not change the surface TM expression of endothelial cells. SDF-1 could enhance low-dose ADP induced platelet aggregation, although it failed by itself to induce aggregation. These findings suggest that plasma SDF-1 might be closely associated with hypercoagulability though its action as a platelet activator.
ISSN
0049-3848 (Print)
Language
English
URI
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1C-4MVDVDC-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=af0289da6f3a27e4fc67d592dc48a0f1

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17239427

http://hdl.handle.net/10371/16138
DOI
https://doi.org/10.1016/j.thromres.2006.11.011
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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