S-Space College of Medicine/School of Medicine (의과대학/대학원) Laboratory Medicine (검사의학전공) Journal Papers (저널논문_검사의학전공)
Plasma level of stromal derived factor-1 (SDF-1) is increased in disseminated intravascular coagulation patients who have poor outcomes: in vitro effect of SDF-1 on coagulopathy
- Kim, Hyun Kyung; Kim, Ji-Eun; Chung, Junho; Lee, Dong Soon; Han, Kyou-Sup; Park, Seonyang; Cho, Han-Ik
- Issue Date
- Thromb Res. 2007;120(4):559-66. Epub 2007 Jan 18.
- Cells, Cultured; Chemokine CXCL12; Chemokines, CXC/*blood/pharmacology; Disseminated Intravascular Coagulation/*blood; Endothelial Cells/metabolism; Humans; Monocytes/metabolism; Platelet Function Tests; Prognosis; Thrombomodulin/drug effects; Thrombophilia/*etiology; Thromboplastin/drug effects
- Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine that activates and directs the migration of leukocytes that have CXCR4, which is the unique receptor for SDF-1. Although SDF-1/CXCR4 interaction has been implicated in various inflammatory conditions, its role in modulating coagulation has not been determined. We studied the plasma SDF-1 levels in 90 patients with suspected disseminated intravascular coagulation (DIC) and we found that circulating SDF-1 was significantly increased in the overt DIC patients and was also increased in overt DIC patients who have a poor outcome. We then tested in vitro whether SDF-1 can affect the expression of monocyte tissue factor (TF) and endothelial thrombomodulin (TM), and both of these play important roles in coagulopathy. SDF-1 did not affect the expression of surface TF protein and its function and the TF mRNA level in both monocytes and the monocytic leukemia cell line THP-1. SDF-1 also did not change the surface TM expression of endothelial cells. SDF-1 could enhance low-dose ADP induced platelet aggregation, although it failed by itself to induce aggregation. These findings suggest that plasma SDF-1 might be closely associated with hypercoagulability though its action as a platelet activator.
- 0049-3848 (Print)
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