Publications
Detailed Information
Plasma level of stromal derived factor-1 (SDF-1) is increased in disseminated intravascular coagulation patients who have poor outcomes: in vitro effect of SDF-1 on coagulopathy
Cited 5 time in
Web of Science
Cited 4 time in Scopus
- Authors
- Issue Date
- 2007-01-24
- Publisher
- Elsevier
- Citation
- Thromb Res. 2007;120(4):559-66. Epub 2007 Jan 18.
- Keywords
- Cells, Cultured ; Chemokine CXCL12 ; Chemokines, CXC/*blood/pharmacology ; Disseminated Intravascular Coagulation/*blood ; Endothelial Cells/metabolism ; Humans ; Monocytes/metabolism ; Platelet Function Tests ; Prognosis ; Thrombomodulin/drug effects ; Thrombophilia/*etiology ; Thromboplastin/drug effects
- Abstract
- Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine that activates and directs the migration of leukocytes that have CXCR4, which is the unique receptor for SDF-1. Although SDF-1/CXCR4 interaction has been implicated in various inflammatory conditions, its role in modulating coagulation has not been determined. We studied the plasma SDF-1 levels in 90 patients with suspected disseminated intravascular coagulation (DIC) and we found that circulating SDF-1 was significantly increased in the overt DIC patients and was also increased in overt DIC patients who have a poor outcome. We then tested in vitro whether SDF-1 can affect the expression of monocyte tissue factor (TF) and endothelial thrombomodulin (TM), and both of these play important roles in coagulopathy. SDF-1 did not affect the expression of surface TF protein and its function and the TF mRNA level in both monocytes and the monocytic leukemia cell line THP-1. SDF-1 also did not change the surface TM expression of endothelial cells. SDF-1 could enhance low-dose ADP induced platelet aggregation, although it failed by itself to induce aggregation. These findings suggest that plasma SDF-1 might be closely associated with hypercoagulability though its action as a platelet activator.
- ISSN
- 0049-3848 (Print)
- Language
- English
- URI
- http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1C-4MVDVDC-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=af0289da6f3a27e4fc67d592dc48a0f1
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17239427
https://hdl.handle.net/10371/16138
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.