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BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Najin | - |
dc.contributor.author | Kim, Sungdae | - |
dc.contributor.author | Nahm, Minyeop | - |
dc.contributor.author | Kopke, Danielle | - |
dc.contributor.author | Kim, Joohyung | - |
dc.contributor.author | Cho, Eunsang | - |
dc.contributor.author | Lee, Min-Jung | - |
dc.contributor.author | Lee, Mihye | - |
dc.contributor.author | Kim, Seung Hyun | - |
dc.contributor.author | Broadie, Kendal | - |
dc.contributor.author | Lee, Seungbok | - |
dc.creator | 이승복 | - |
dc.date.accessioned | 2020-01-23T07:24:20Z | - |
dc.date.available | 2020-04-05T07:24:20Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.citation | Nature Communications, Vol.10 No.1, p. 684 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://hdl.handle.net/10371/163568 | - |
dc.description.abstract | Retrograde BMP trans-synaptic signaling is essential for synaptic development. Despite the importance of endocytosis-regulated BMP receptor (BMPR) control of this developmental signaling, the mechanism remains unknown. Here, we provide evidence that Abelson interactor (Abi), a substrate for Abl kinase and component of the SCAR/WAVE complex, links Abl and Rac1 GTPase signaling to BMPR macropinocytosis to restrain BMP-mediated synaptic development. We find that Abi acts downstream of Abl and Rac1, and that BMP ligand Glass bottom boat (Gbb) induces macropinocytosis dependent on Rac1/SCAR signaling, Abl-mediated Abi phosphorylation, and BMPR activation. Macropinocytosis acts as the major internalization route for BMPRs at the synapse in a process driven by Gbb activation and resulting in receptor degradation. Key regulators of macropinocytosis (Rabankyrin and CtBP) control BMPR trafficking to limit BMP trans-synaptic signaling. We conclude that BMP-induced macropinocytosis acts as a BMPR homeostatic mechanism to regulate BMP-mediated synaptic development. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | en |
dc.publisher | Nature Publishing Group | - |
dc.title | BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41467-019-08533-2 | - |
dc.citation.journaltitle | Nature Communications | - |
dc.identifier.wosid | 000458176000001 | - |
dc.identifier.scopusid | 2-s2.0-85061295220 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201900039 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A075729 | - |
dc.description.srnd | CITE_RATE:12.353 | - |
dc.description.srnd | DEPT_NM:뇌인지과학과 | - |
dc.description.srnd | EMAIL:seunglee@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 684 | - |
dc.citation.volume | 10 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, Seungbok | - |
dc.identifier.srnd | T201900039 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NERVOUS WRECK | - |
dc.subject.keywordPlus | MACROPINOSOME FORMATION | - |
dc.subject.keywordPlus | INTERACTING PROTEIN | - |
dc.subject.keywordPlus | TYROSINE KINASE | - |
dc.subject.keywordPlus | II RECEPTOR | - |
dc.subject.keywordPlus | DROSOPHILA | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | WAVE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | STABILITY | - |
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