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TM4SF5-mediated CD44v8-10 splicing variant promotes survival of type II alveolar epithelial cells during idiopathic pulmonary fibrosis
DC Field | Value | Language |
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dc.contributor.author | Kim, Ji Eon | - |
dc.contributor.author | Kim, Hye-Jin | - |
dc.contributor.author | Jung, Jae Woo | - |
dc.contributor.author | Song, Dae-Geun | - |
dc.contributor.author | Park, Dasomi | - |
dc.contributor.author | Lee, Haesong | - |
dc.contributor.author | Um, Hyejin | - |
dc.contributor.author | Park, Jinsoo | - |
dc.contributor.author | Nam, Seo Hee | - |
dc.contributor.author | Cho, Moonjae | - |
dc.contributor.author | Lee, Jung Weon | - |
dc.creator | 이정원 | - |
dc.date.accessioned | 2020-01-23T07:29:35Z | - |
dc.date.available | 2020-04-05T07:29:35Z | - |
dc.date.created | 2019-10-11 | - |
dc.date.issued | 2019-09 | - |
dc.identifier.citation | Cell Death and Disease, Vol.10 No.9, p. 645 | - |
dc.identifier.issn | 2041-4889 | - |
dc.identifier.uri | https://hdl.handle.net/10371/163718 | - |
dc.description.abstract | Reactive oxygen species (ROS) regulate cell fate, although signaling molecules that regulate ROS hormesis remain unclear. Here we show that transmembrane 4 L six family member 5 (TM4SF5) in lung epithelial cells induced the alternatively spliced CD44v8-10 variant via an inverse ZEB2/epithelial splicing regulatory proteins (ESRPs) linkage. TM4SF5 formed complexes with the cystine/glutamate antiporter system via TM4SF5- and CD44v8-10-dependent CD98hc plasma-membrane enrichment. Dynamic TM4SF5 binding to CD98hc required CD44v8-10 under ROS-generating inflammatory conditions. TM4SF5 and CD44v8-10 upregulated cystine/glutamate antiporter activity and intracellular glutathione levels, leading to ROS modulation for cell survival. Tm4sf5-null mice exhibited attenuated bleomycin-induced pulmonary fibrosis with lower CD44v8-10 and ESRPs levels than wild-type mice. Primary mouse alveolar epithelial cells (AECs) revealed type II AECs (AECII), but not type I, to adapt the TM4SF5-mediated characteristics, suggesting TM4SF5-mediated AECII survival following AECI injury during idiopathic pulmonary fibrosis (IPF). Thus, the TM4SF5-mediated CD44v8-10 splice variant could be targeted against IPF. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | en |
dc.publisher | Nature Publishing Group | - |
dc.title | TM4SF5-mediated CD44v8-10 splicing variant promotes survival of type II alveolar epithelial cells during idiopathic pulmonary fibrosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41419-019-1878-5 | - |
dc.citation.journaltitle | Cell Death and Disease | - |
dc.identifier.wosid | 000494969700004 | - |
dc.identifier.scopusid | 2-s2.0-85071993250 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201911399 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A078142 | - |
dc.description.srnd | CITE_RATE:5.638 | - |
dc.description.srnd | FILENAME:109-JEK-CDDIS.pdf | - |
dc.description.srnd | DEPT_NM:약학과 | - |
dc.description.srnd | EMAIL:jwl@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | FILEURL:https://srnd.snu.ac.kr/eXrepEIR/fws/file/867ea207-28f4-4911-8c6b-6b70e8403930/link | - |
dc.citation.number | 9 | - |
dc.citation.startpage | 645 | - |
dc.citation.volume | 10 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, Jung Weon | - |
dc.identifier.srnd | T201911399 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | TM4SF5 | - |
dc.subject.keywordPlus | CD44 | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | REPAIR | - |
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