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LRRK2 and membrane trafficking: nexus of Parkinson's disease

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Authors
Hur, Eun-Mi; Jang, Eun-Hae; Jeong, Ga Ram; Lee, Byoung Dae
Issue Date
2019-09
Publisher
생화학분자생물학회
Citation
BMB Reports, Vol.52 No.9, pp.533-539
Abstract
Recent evidence from genetics, animal model systems and biochemical studies suggests that defects in membrane trafficking play an important part in the pathophysiology of Parkinson's disease (PD). Mutations in leucine-rich repeat kinase 2 (LRRK2) constitute the most frequent genetic cause of both familial and sporadic PD, and LRRK2 has been suggested as a druggable target for PD. Although the precise physiological function of LRRK2 remains largely unknown, mounting evidence suggests that LRRK2 controls membrane trafficking by interacting with key regulators of the endosomal-lysosomal pathway and synaptic recycling. In this review, we discuss the genetic, biochemical and functional links between LRRK2 and membrane trafficking. Understanding the mechanism by which LRRK2 influences such processes may contribute to the development of disease-modifying therapies for PD.
ISSN
1976-6696
Language
ENG
URI
https://hdl.handle.net/10371/163767
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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