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An umbrella study of biomarker-driven targeted therapy in patients with platinum-resistant recurrent ovarian cancer: a Korean Gynecologic Oncology Group study (KGOG 3045), AMBITION
DC Field | Value | Language |
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dc.contributor.author | Lee, Jung-Yun | - |
dc.contributor.author | Yi, Ju Yeon | - |
dc.contributor.author | Kim, Hyun-Soo | - |
dc.contributor.author | Lim, June | - |
dc.contributor.author | Kim, Sunghoon | - |
dc.contributor.author | Nam, Byoung Ho | - |
dc.contributor.author | Kim, Hee Seung | - |
dc.contributor.author | Kim, Jae Weon | - |
dc.contributor.author | Choi, Chel Hun | - |
dc.contributor.author | Kim, Byoung-Gie | - |
dc.creator | 김희승 | - |
dc.date.accessioned | 2020-01-23T07:41:29Z | - |
dc.date.available | 2020-04-05T07:41:29Z | - |
dc.date.created | 2019-12-04 | - |
dc.date.created | 2019-12-04 | - |
dc.date.created | 2019-12-04 | - |
dc.date.issued | 2019-08 | - |
dc.identifier.citation | Japanese Journal of Clinical Oncology, Vol.49 No.8, pp.789-792 | - |
dc.identifier.issn | 0368-2811 | - |
dc.identifier.uri | https://hdl.handle.net/10371/163921 | - |
dc.description.abstract | A pilot study of biomarker-driven targeted therapy in patients with platinum-resistant recurrent ovarian cancer has been started in Korea. Archival tumor samples were tested for HRD and PD-L1 status. Treatment arms will be allocated according to the test results. For HRD+ patients, we tested the synergistic effects of olaparib and other agents; treatment arms will randomly be allocated. (Arm 1: olaparib and cediranib; Arm 2: olaparib and durvalumab). For HRD- patients, we tested the role of biomarker-driven immunotherapy according to PD-L1 expression (Arm 3: durvalumab and chemotherapy in patients with high PD-L1 expression; Arm 4: durvalumab, tremelimumab, and chemotherapy in patients with low PD-L1 expression). Sixty-eight patients will be included from three Korean institutions within 1 year. The primary endpoint is the response rate according to RECIST 1.1 (6 months after treatment initiation). | - |
dc.language | 영어 | - |
dc.language.iso | ENG | en |
dc.publisher | Oxford University Press | - |
dc.title | An umbrella study of biomarker-driven targeted therapy in patients with platinum-resistant recurrent ovarian cancer: a Korean Gynecologic Oncology Group study (KGOG 3045), AMBITION | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/jjco/hyz085 | - |
dc.citation.journaltitle | Japanese Journal of Clinical Oncology | - |
dc.identifier.wosid | 000493068900016 | - |
dc.identifier.scopusid | 2-s2.0-85074351167 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201916095 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A080402 | - |
dc.description.srnd | CITE_RATE:2.183 | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | EMAIL:bboddi0311@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.citation.endpage | 792 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 789 | - |
dc.citation.volume | 49 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Hee Seung | - |
dc.identifier.srnd | T201916095 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordAuthor | platinum-resistant | - |
dc.subject.keywordAuthor | ovarian cancer | - |
dc.subject.keywordAuthor | biomarker | - |
dc.subject.keywordAuthor | umbrella study | - |
dc.subject.keywordAuthor | targeted therapy | - |
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