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Antitumor effect of TW-37, a BH3 mimetic in human oral cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, Chi-Hyun | - |
dc.contributor.author | Lee, Won Woo | - |
dc.contributor.author | Jung, Yun Chan | - |
dc.contributor.author | Shin, Ji-Ae | - |
dc.contributor.author | Hong, Kyoung-Ok | - |
dc.contributor.author | Choi, Sujung | - |
dc.contributor.author | Swarup, Neeti | - |
dc.contributor.author | Kim, Jihoon | - |
dc.contributor.author | Ahn, Min-Hye | - |
dc.contributor.author | Jung, Minjung | - |
dc.contributor.author | Cho, Sung-Dae | - |
dc.contributor.author | Jin, Bohwan | - |
dc.date.accessioned | 2020-03-27T02:17:05Z | - |
dc.date.available | 2020-04-05T11:20:14Z | - |
dc.date.issued | 2019-12-04 | - |
dc.identifier.citation | Laboratory Animal Research, 35(1):27 | ko_KR |
dc.identifier.issn | 2233-7660 | - |
dc.identifier.uri | 10.1186/s42826-019-0028-7 | - |
dc.identifier.uri | https://hdl.handle.net/10371/164791 | - |
dc.description.abstract | TW-37 is a small molecule B cell lymphoma-2 (Bcl-2) homology 3 mimetic with potential anticancer activities. However, the in vivo anti-cancer effect of TW-37 in human oral cancer has not been properly studied yet. Here, we attempted to confirm antitumor activity of TW37 in human oral cancer. TW-37 significantly inhibited cell proliferation and increased the number of dead cells in MC-3 and HSC-3 human oral cancer cell lines. TW-37 enhanced apoptosis of both cell lines evidenced by annexin V/propidium iodide double staining, sub-G1 population analysis and the detection of cleaved poly (ADP-ribose) polymerase and caspase-3. In addition, TW-37 markedly downregulated the expression of Bcl-2 protein, while not affecting Bcl-xL or myeloid cell leukemia-1. In vivo, TW-37 inhibited tumor growth in a nude mice xenograft model without any significant liver and kidney toxicities. Collectively, these data reveal that TW-37 may be a promising small molecule to inhibit human oral cancer. | ko_KR |
dc.description.sponsorship | This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science ICT & Future Planning [2019R1A2C1085896]. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | TW-37 | - |
dc.subject | Apoptosis | - |
dc.subject | Bcl-2 | - |
dc.subject | Oral cancer | - |
dc.title | Antitumor effect of TW-37, a BH3 mimetic in human oral cancer | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 안지현 | - |
dc.contributor.AlternativeAuthor | 이원우 | - |
dc.contributor.AlternativeAuthor | 정윤찬 | - |
dc.contributor.AlternativeAuthor | 신지애 | - |
dc.contributor.AlternativeAuthor | 홍경옥 | - |
dc.contributor.AlternativeAuthor | 최수정 | - |
dc.contributor.AlternativeAuthor | 김지훈 | - |
dc.contributor.AlternativeAuthor | 안민혜 | - |
dc.contributor.AlternativeAuthor | 조성대 | - |
dc.contributor.AlternativeAuthor | 진보환 | - |
dc.citation.journaltitle | Laboratory Animal Research | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2019-12-08T04:14:14Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 27 | ko_KR |
dc.citation.volume | 35 | ko_KR |
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