Browse

Comparative pathologic analysis of mediastinal B-cell lymphomas: selective expression of p63 but no GATA3 optimally differentiates primary mediastinal large B-cell lymphoma from classic Hodgkin lymphoma

DC Field Value Language
dc.contributor.authorKim, Hyun-Jung-
dc.contributor.authorKim, Hee Kyung-
dc.contributor.authorPark, Gyeongsin-
dc.contributor.authorMin, Soo Kee-
dc.contributor.authorCha, Hee Jeong-
dc.contributor.authorLee, Hyekyung-
dc.contributor.authorChoi, Suk Jin-
dc.contributor.authorNa, Hee Young-
dc.contributor.authorChoe, Ji-Young-
dc.contributor.authorKim, Ji Eun-
dc.date.accessioned2020-03-27T06:36:51Z-
dc.date.available2020-04-05T15:37:46Z-
dc.date.issued2019-12-12-
dc.identifier.citationDiagnostic Pathology, 14(1):133ko_KR
dc.identifier.issn1746-1596-
dc.identifier.uri10.1186/s13000-019-0918-x-
dc.identifier.urihttps://hdl.handle.net/10371/164793-
dc.description.abstractBackground
Interpretation of mediastinal biopsy is often challenging even for experienced pathologists especially when a hematolymphoid neoplasm is suspected. Primary mediastinal large B-cell lymphoma (PMLBCL) and classic Hodgkin lymphoma (CHL) represent two major types of mature B-cell lymphomas of the mediastinum. Although PMLBCL and mediastinal CHL share many clinicopathologic characteristics, their treatment strategies and responses are remarkably different. We therefore aimed to find distinctive histologic or protein markers to better differentiate these two lesions.

Methods
Search for primary mediastinal B-cell lymphomas found 52 consecutive cases from 3 university hospitals of Korea during 2005 to 2012. Among them, 32 cases that were available for additional immunohistochemistry (IHC) assessment were enrolled in this study. These cases consisted of the following: CHL (N = 13), PMLBCL (N = 16), and B-cell lymphoma unclassifiable, with features intermediate between diffuse large B-cell lymphoma and CHL (gray zone lymphoma, N = 3). Along with the clinicopathologic findings, the expression of p63, GATA3 and cyclin E was investigated by IHC in the three categorized lesions mentioned above.

Results
Most clinical features overlapped between PMLBCL and CHL except for the increased disease progression and mortality found in PMLBCL. In the pathologic review, the presence of epithelioid granuloma favored a diagnosis of CHL, whereas reticulated or alveolar patterns of fibrosis were characteristic of PMLBCL. For protein markers, p63 was predominantly positive in PMLBCL (15/16) compared with CHL (2/13), which indicates that p63 is a marker of the highest diagnostic accuracy when calculated by the area under the ROC curve. GATA3 was expressed in the majority of CHL cases (10/13) compared with PMLBCL (0/16), while the expression of cyclin E was only rarely present in a minor population of PMLBCL.

Conclusions
P63 expression in tumor cells, even focal expression, and no GATA3 is the most helpful feature in distinguishing PMLBCL from mediastinal CHL.
ko_KR
dc.description.sponsorshipThis study was supported by a grant-in-aid for Scientific Research from Inje University Research Foundation (20180109) to Hyun-Jung Kim.ko_KR
dc.language.isoenko_KR
dc.publisherBMCko_KR
dc.subjectPrimary mediastinal large B-cell lymphoma-
dc.subjectClassic Hodgkin lymphoma-
dc.subjectp63-
dc.subjectGATA3-
dc.subjectCyclin E-
dc.subjectImmunohistochemistry-
dc.titleComparative pathologic analysis of mediastinal B-cell lymphomas: selective expression of p63 but no GATA3 optimally differentiates primary mediastinal large B-cell lymphoma from classic Hodgkin lymphomako_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김현정-
dc.contributor.AlternativeAuthor김희경-
dc.contributor.AlternativeAuthor박경신-
dc.contributor.AlternativeAuthor민수기-
dc.contributor.AlternativeAuthor차희정-
dc.contributor.AlternativeAuthor이혜경-
dc.contributor.AlternativeAuthor최숙진-
dc.contributor.AlternativeAuthor나희영-
dc.contributor.AlternativeAuthor최지영-
dc.contributor.AlternativeAuthor김지은-
dc.citation.journaltitleDiagnostic Pathologyko_KR
dc.language.rfc3066en-
dc.rights.holderThe Author(s).-
dc.date.updated2019-12-15T08:55:34Z-
dc.citation.number1ko_KR
dc.citation.startpage133ko_KR
dc.citation.volume14ko_KR
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
Files in This Item:
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse