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Systematic analysis of expression signatures of neuronal subpopulations in the VTA

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dc.contributor.authorKim, Hyun Jin-
dc.contributor.authorKim, Minhyung-
dc.contributor.authorKang, Byeongsoo-
dc.contributor.authorYun, Soyeon-
dc.contributor.authorRyeo, Shin Eun-
dc.contributor.authorHwang, Daehee-
dc.contributor.authorKim, Joung-Hun-
dc.date.accessioned2020-03-27T06:42:06Z-
dc.date.available2020-04-05T15:43:34Z-
dc.date.issued2019-12-11-
dc.identifier.citationMolecular Brain, 12(1):110ko_KR
dc.identifier.issn1756-6606-
dc.identifier.uri10.1186/s13041-019-0530-8-
dc.identifier.urihttps://hdl.handle.net/10371/164794-
dc.description.abstractGene expression profiling across various brain areas at the single-cell resolution enables the identification of molecular markers of neuronal subpopulations and comprehensive characterization of their functional roles. Despite the scientific importance and experimental versatility, systematic methods to analyze such data have not been established yet. To this end, we developed a statistical approach based on in situ hybridization data in the Allen Brain Atlas and thereby identified specific genes for each type of neuron in the ventral tegmental area (VTA). This approach also allowed us to demarcate subregions within the VTA comprising specific neuronal subpopulations. We further identified WW domain-containing oxidoreductase as a molecular marker of a population of VTA neurons that co-express tyrosine hydroxylase and vesicular glutamate transporter 2, and confirmed their region-specific distribution by immunohistochemistry. The results demonstrate the utility of our analytical approach for uncovering expression signatures representing specific cell types and neuronal subpopulations enriched in a given brain area.ko_KR
dc.description.sponsorshipThis work was supported by the grants from National Research Foundations of Korean Ministry of Science and ICT (2018M3C7A1024152, 2018R1A3B1052079, 2019M3A9B6066967, and 2019R1A6A1A10073437) and the Institute for Basic Science (IBS-R013-A1).ko_KR
dc.language.isoenko_KR
dc.publisherBMCko_KR
dc.subjectAllen brain atlas-
dc.subjectGene expression profile-
dc.subjectVTA-
dc.subjectCell type markers-
dc.titleSystematic analysis of expression signatures of neuronal subpopulations in the VTAko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김현진-
dc.contributor.AlternativeAuthor김민형-
dc.contributor.AlternativeAuthor강병수-
dc.contributor.AlternativeAuthor윤소연-
dc.contributor.AlternativeAuthor려신은-
dc.contributor.AlternativeAuthor황대희-
dc.contributor.AlternativeAuthor김중헌-
dc.citation.journaltitleMolecular Brainko_KR
dc.language.rfc3066en-
dc.rights.holderThe Author(s).-
dc.date.updated2019-12-15T08:56:10Z-
dc.citation.number1ko_KR
dc.citation.startpage110ko_KR
dc.citation.volume12ko_KR
Appears in Collections:
College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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