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Inaccuracy of intraocular pressure measurement in congenital corneal opacity: three case reports

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Authors
Kang, Byeong Soo; Jeoung, Jin Wook; Oh, Joo Youn
Issue Date
2020-01-02
Publisher
BMC
Citation
BMC Ophthalmology, 20(1):3
Keywords
Applanation-based tonometryCase reportCongenital corneal opacityCongenital glaucomaIntraocular pressure
Abstract
Background
To report three cases of congenital corneal opacity where intraocular pressure (IOP) readings were high despite the use of multiple anti-glaucoma eye drops and normalized after corneal transplantation.

Case presentation
Three Korean infants presented with bilateral dense stromal opacification which had been present since birth. IOPs measured by rebound tonometer were high despite administration of multiple anti-glaucoma medications. One eye of each patient underwent penetrating keratoplasty (PK) because corneal opacity impaired visual development. Immediately after PK, IOPs were normalized and maintained normal without medication, whereas they remained high in the contralateral unoperated eye. On histology, stromal fibrosis was observed in the removed corneal button, and molecular assays revealed increased levels of type 1 and 5 collagens.

Conclusion
The IOP measurement using the conventional applanation-based tonometry can be inaccurate in congenital corneal opacity which is marked by corneal fibrosis. Therefore, IOP values should be interpreted with caution in these patients, and the possibility of false-positive diagnosis of glaucoma considered.
ISSN
1471-2415
Language
English
URI
https://doi.org/10.1186/s12886-019-1287-7

https://hdl.handle.net/10371/164891
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College of Medicine/School of Medicine (의과대학/대학원)Ophthalmology (안과학전공)Journal Papers (저널논문_안과학전공)
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