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Low-density lipoprotein cholesterol goal attainment rates in high-risk patients with cardiovascular diseases and diabetes mellitus in Korea: a retrospective cohort study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Ye Seul | - |
dc.contributor.author | Yang, Bo Ram | - |
dc.contributor.author | Kim, Mi-Sook | - |
dc.contributor.author | Hwang, Yunji | - |
dc.contributor.author | Choi, Sung Hee | - |
dc.date.accessioned | 2020-04-03T06:04:13Z | - |
dc.date.available | 2020-04-03T15:05:12Z | - |
dc.date.issued | 2020-01-11 | - |
dc.identifier.citation | Lipids in Health and Disease, 19(1):5 | ko_KR |
dc.identifier.issn | 1476-511X | - |
dc.identifier.uri | 10.1186/s12944-019-1158-5 | - |
dc.identifier.uri | https://hdl.handle.net/10371/164916 | - |
dc.description.abstract | Background
Real-world evidence of low-density lipoprotein cholesterol (LDL-C) goal attainment rates for Asian patients is deficient. The objective of this study was to assess the status of dyslipidemia management, especially in high-risk patients with cardiovascular disease (CVD) including stroke and acute coronary syndrome (ACS). Methods This was a retrospective cohort study of 514,866 subjects from the National Health Insurance Service-National Health Screening Cohort database in Korea. Participants were followed up from 2002 to 2015. Subjects with a high-risk of CVD prior to LDL-C measurement and subjects who were newly-diagnosed for high-risk of CVD following LDL-C measurement were defined as known high-risk patients (n = 224,837) and newly defined high-risk patients (n = 127,559), respectively. Data were analyzed by disease status: stroke, ACS, coronary heart disease (CHD), peripheral artery disease (PAD), diabetes mellitus (DM) and atherosclerotic artery disease (AAD). Results Overall, less than 50% of patients in each disease category achieved LDL-C goals (LDL-C < 70 mg/dL in patients with stroke, ACS, CHD and PAD; and LDL-C < 100 mg/dL in patients with DM and AAD). Statin use was observed in relatively low proportions of subjects (21.5% [known high-risk], 34.4% [newly defined high-risk]). LDL-C goal attainment from 2009 to 2015 steadily increased but the goal-achiever proportion of newly defined high-risk patients with ACS remained reasonably constant (38.7% in 2009; 38.1% in 2015). Conclusions LDL-C goal attainment rates in high-risk patients with CVD and DM in Korea demonstrate unmet medical needs. Proactive management is necessary to bridge the gap between the recommendations of clinical guidelines and actual clinical practice. | ko_KR |
dc.description.sponsorship | This study was supported by a research grant from Amgen, Inc. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Dyslipidaemia | - |
dc.subject | Low density lipoprotein cholesterol | - |
dc.subject | Stroke | - |
dc.subject | Acute coronary syndrome | - |
dc.subject | Cardiovascular disease | - |
dc.subject | Diabetes mellitus | - |
dc.subject | Statin | - |
dc.title | Low-density lipoprotein cholesterol goal attainment rates in high-risk patients with cardiovascular diseases and diabetes mellitus in Korea: a retrospective cohort study | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 양예슬 | - |
dc.contributor.AlternativeAuthor | 양보람 | - |
dc.contributor.AlternativeAuthor | 김미숙 | - |
dc.contributor.AlternativeAuthor | 황윤지 | - |
dc.contributor.AlternativeAuthor | 최성희 | - |
dc.citation.journaltitle | Lipids in Health and Disease | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2020-01-12T04:46:15Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 5 | ko_KR |
dc.citation.volume | 19 | ko_KR |
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